Informations générales (source: ClinicalTrials.gov)
A Randomised, Double-blind, Active-controlled 52-week Study With an Open-label Extension to Evaluate the Efficacy and Safety of Benralizumab Compared to Mepolizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis (EGPA) in Patients Receiving Standard of Care Therapy (MANDARA Study) (MANDARA)
Interventional
Phase 3
AstraZeneca (Voir sur ClinicalTrials)
octobre 2019
mars 2026
30 avril 2025
This is a randomized, double blind, active-controlled, parallel group, multicenter
52-week Phase 3 study to compare the efficacy and safety of benralizumab 30 mg versus
mepolizumab 300 mg administered by subcutaneous (SC) injection in patients with relapsing
or refractory EGPA on corticosteroid therapy with or without stable immunosuppressive
therapy.
All patients who complete the 52-week double-blind treatment period on IP may be eligible
to continue into an open label extension (OLE) period. The OLE period is intended to
allow each patient at least 1 year of treatment with open-label benralizumab 30 mg
administered SC (earlier enrolled patients may therefore be in the OLE for longer than 1
year).
Etablissements
| Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| HOPITAL FOCH | jeudi 19 juin 2025 | Contact (sur clinicalTrials) | |||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Research Site - 13915 - Marseille - France | Contact (sur clinicalTrials) | ||||
| Research Site - 21079 - Dijon Cedex - France | Contact (sur clinicalTrials) | ||||
| Research Site - 31059 - Toulouse - France | Contact (sur clinicalTrials) | ||||
| Research Site - 34090 - Montpellier - France | Contact (sur clinicalTrials) | ||||
| Research Site - 44093 - Nantes Cedex 1 - France | Contact (sur clinicalTrials) | ||||
| Research Site - 75014 - Paris - France | Contact (sur clinicalTrials) | ||||
| Research Site - 75877 - Paris - France | Contact (sur clinicalTrials) | ||||
| Research Site - 92151 - Suresnes Cedex - France | Contact (sur clinicalTrials) | ||||
Critères
Tous
Inclusion Criteria:
1. Male or female subjects age 18 years or older.
2. EGPA diagnosis based on history or presence asthma and eosinophilia (>1.0x10^9/L
and/or >10% of leucocytes) and at least 2 of; biopsy with eosinophilic vasculitis or
perivascular/granulomatous inflammation; mono-or polyneuropathy, non-fixed pulmonary
infiltrates, sino-nasal abnormality; cardiomyopathy; glomerulonephritis; alveolar
haemorrhage; palpable purpura; anti neutrophil cytoplasmic anti-body (ANCA)
positivity (Myeloperoxidase or proteinease 3).
3. History of relapsing (at least 1 confirmed EGPA relapse within last 2 years and > 12
weeks prior to screening), or refractory (failure to attain remission, defined as
BVAS=0 and oral corticosteroid (OCS) dose <=7.5 mg/day of prednisolone or
equivalent, following standard induction regimen for at least 3 months and within 6
months prior to screening, or recurrence of symptoms upon OCS tapering at any dose
of ≥7.5 mg/day prednisolone or equivalent.
If induction with glucocorticoidsalone, patient must have failed to attain remission
after 3 months and the glucocorticoid dose must be ≥15 mg/day prednisolone or
equivalent for the 4 weeks prior to randomization.
4. Must be on a stable dose of oral prednisolone or prednisone of ≥7.5 mg/day (but not
>50mg/day) for at least 4 weeks prior to randomization.
5. If receiving immunosuppressive therapy (excluding cyclophosphamide) the dose must be
stable for the 4 weeks prior to randomization and during the study (dose reductions
for safety reasons will be permitted).
6. QTc(F)<450 msec or QTc(F)<480 msec for patients with bundle branch block.
7. Females of childbearing potential must use an acceptable method of birth control
from randomization for at least 12 weeks after the last study drug administration.
1. Male or female subjects age 18 years or older.
2. EGPA diagnosis based on history or presence asthma and eosinophilia (>1.0x10^9/L
and/or >10% of leucocytes) and at least 2 of; biopsy with eosinophilic vasculitis or
perivascular/granulomatous inflammation; mono-or polyneuropathy, non-fixed pulmonary
infiltrates, sino-nasal abnormality; cardiomyopathy; glomerulonephritis; alveolar
haemorrhage; palpable purpura; anti neutrophil cytoplasmic anti-body (ANCA)
positivity (Myeloperoxidase or proteinease 3).
3. History of relapsing (at least 1 confirmed EGPA relapse within last 2 years and > 12
weeks prior to screening), or refractory (failure to attain remission, defined as
BVAS=0 and oral corticosteroid (OCS) dose <=7.5 mg/day of prednisolone or
equivalent, following standard induction regimen for at least 3 months and within 6
months prior to screening, or recurrence of symptoms upon OCS tapering at any dose
of ≥7.5 mg/day prednisolone or equivalent.
If induction with glucocorticoidsalone, patient must have failed to attain remission
after 3 months and the glucocorticoid dose must be ≥15 mg/day prednisolone or
equivalent for the 4 weeks prior to randomization.
4. Must be on a stable dose of oral prednisolone or prednisone of ≥7.5 mg/day (but not
>50mg/day) for at least 4 weeks prior to randomization.
5. If receiving immunosuppressive therapy (excluding cyclophosphamide) the dose must be
stable for the 4 weeks prior to randomization and during the study (dose reductions
for safety reasons will be permitted).
6. QTc(F)<450 msec or QTc(F)<480 msec for patients with bundle branch block.
7. Females of childbearing potential must use an acceptable method of birth control
from randomization for at least 12 weeks after the last study drug administration.
1. Diagnosed with granulomatosis with polyangiitis (GPA) or microscopic polyangiitis
(MPA)
2. Organ or life-threatening EGPA < 3 months prior to screening
3. Currently pregnant or breastfeeding, or planning to become pregnant during study
participation.
4. Current malignancy or history of malignancy, unless received curative therapy >5
years ago, or >1 year ago for basal cell carcinoma, localized squamous cell
carcinoma of the skin or in situ carcinoma of the cervix
5. An untreated or refractory helminth parasitic infection < 24 weeks prior to
screening
6. Unstable liver disease
7. Severe or clinically significant, uncontrolled cardiovascular disease
8. Other concurrent disease that may put the patient at risk, or may influence the
results of the study, or the patients' ability to complete entire duration of the
study
9. Chronic or ongoing infectious disease requiring systemic anti-infective treatment
10. Known immunodeficiency disorder or positive HIV test
11. Prior receipt of mepolizumab, reslizumab, dupilumab or benralizumab. Receipt of
intravenous/intramuscular/subcutaneous corticosteroids within 4 weeks prior to
randomization, receipt of omalizumab within 130 days prior to screening, rituximab
within 6 months prior to screening (or B-cells not recovered), interferon-α or
alemtuzumab within 6 months prior to screening, receipt of anti-tumor necrosis
factor therapy within 12 weeks prior to screening or an investigational non-biologic
product within 30 days or 5 half-lives prior to screening, whichever is longer.
Receipt of any other marketed or investigational biologic products within 4 months
or 5 half-lives prior to screening, whichever is longer.