Informations générales (source: ClinicalTrials.gov)
Phase III Randomised Study Of Adjuvant Paclitaxel And Carboplatin (TAXOL-PARAPLATINE) With Concomittant Radiotherapy In Patients With Stage II or III Non-Metastatic Non-Small Cell Lung Cancer
Interventional
Phase 3
GERCOR - Multidisciplinary Oncology Cooperative Group (Voir sur ClinicalTrials)
juin 2002
29 juin 2024
RATIONALE: Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in
different ways to stop tumor cells from dividing so they stop growing or die. Radiation
therapy uses high-energy x-rays to damage tumor cells. It is not yet known whether giving
chemotherapy together with radiation therapy is more effective with or without adjuvant
chemotherapy in treating unresectable stage II or stage III non-small cell lung cancer.
PURPOSE: This randomized phase III trial is studying giving paclitaxel, carboplatin, and
radiation therapy together with adjuvant paclitaxel and carboplatin to see how well it
works compared to giving paclitaxel, carboplatin, and radiation therapy alone in treating
patients with unresectable stage II or stage III non-small cell lung cancer.
Etablissements
| Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| AP-HP - Hôpital Avicenne | Contact (sur clinicalTrials) | ||||
| AP-HP - Hôpital Tenon | Contact (sur clinicalTrials) | ||||
| CDS MEDICO-DENTAIRE MONTREUIL ROUGET | Contact (sur clinicalTrials) | ||||
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| C.H.G. Beauvais - 60021 - Beauvais - France | Contact (sur clinicalTrials) | ||||
| C.H.G. De Pau - 64000 - Pau - France | Contact (sur clinicalTrials) | ||||
| Centre D'Oncologie De Gentilly - 54100 - Nancy - France | Contact (sur clinicalTrials) | ||||
| Centre d'Oncologie et de Radiotherapie du Parc - 21000 - Dijon - France | Contact (sur clinicalTrials) | ||||
| Centre Eugene Marquis - 35042 - Rennes - France | Contact (sur clinicalTrials) | ||||
| Centre Frederic Joliot - 76000 - Rouen - France | Contact (sur clinicalTrials) | ||||
| Centre Guillaume Le Conquerant - 76600 - Le Havre - France | Contact (sur clinicalTrials) | ||||
| Centre Hospitalier Bayeux - 14400 - Bayeux - France | Contact (sur clinicalTrials) | ||||
| Centre Hospitalier Chaumont - 52000 - Chaumont - France | Contact (sur clinicalTrials) | ||||
| Centre Hospitalier d'Annecy - 74011 Cedex - Annecy - France | Contact (sur clinicalTrials) | ||||
| Centre Hospitalier de la Cote Basque - 64100 - Bayonne - France | Contact (sur clinicalTrials) | ||||
| Centre Hospitalier de Mulhouse - 68051 - Mulhouse - France | Contact (sur clinicalTrials) | ||||
| Centre Hospitalier de Saint - Brieuc - 22023 - Saint-Brieuc - France | Contact (sur clinicalTrials) | ||||
| Centre Hospitalier De Saint Dizier - 52100 - Saint Dizier - France | Contact (sur clinicalTrials) | ||||
| Centre Hospitalier Regional Metz Thionville - 57126 - Thionville - France | Contact (sur clinicalTrials) | ||||
| Centre Hospitalier Robert Bisson - 14100 - Lisieux - France | Contact (sur clinicalTrials) | ||||
| Centre Jean Bernard - 72000 - Le Mans - France | Contact (sur clinicalTrials) | ||||
| Centre Mallet - Proux - 53000 - Laval - France | Contact (sur clinicalTrials) | ||||
| Centre Regional de Lutte Contre le Cancer - Centre Val d'Aurelle - 34298 - Montpellier - France | Contact (sur clinicalTrials) | ||||
| CHR D'Orleans - Hopital de la Source - 45100 - Orleans - France | Contact (sur clinicalTrials) | ||||
| Clinique Chenieux - 87000 - Limoges - France | Contact (sur clinicalTrials) | ||||
| Clinique de l'Orangerie - 67010 - Strasbourg - France | Contact (sur clinicalTrials) | ||||
| Clinique des Cedres - 31700 - Cornebarrieu - France | Contact (sur clinicalTrials) | ||||
| Clinique du Cedre - 76230 - Bois-Guillaume - France | Contact (sur clinicalTrials) | ||||
| Clinique du Petit Colmouilins - 76700 - Harfleur - France | Contact (sur clinicalTrials) | ||||
| Clinique Pasteur - 27000 - Evreux - France | Contact (sur clinicalTrials) | ||||
| Clinique Saint - Pierre - Perpignan - France | Contact (sur clinicalTrials) | ||||
| Clinique Saint Vincent - 35700 - Saint Gregoire - France | Contact (sur clinicalTrials) | ||||
| Hopital Jean Monnet - BP590 - Epinal - France | Contact (sur clinicalTrials) | ||||
| Hopital Louis Pasteur - 28018 - Chartres - France | Contact (sur clinicalTrials) | ||||
| Hopital Louis Pasteur - 68021 - Comar - France | Contact (sur clinicalTrials) | ||||
| Hopital Notre-Dame de Bon Secours - 55038 - Metz - France | Contact (sur clinicalTrials) | ||||
| Hopital Robert Boulin - 33500 - Libourne - France | Contact (sur clinicalTrials) | ||||
| Hopital Saint Andre - 33075 - Bordeaux - France | Contact (sur clinicalTrials) | ||||
| Hopital Saint-Louis - 75475 - Paris - France | Contact (sur clinicalTrials) | ||||
| Institut Sainte Catherine - 84082 - Avignon - France | Contact (sur clinicalTrials) | ||||
| Maison Medicale Marzet - 64000 - Pau - France | Contact (sur clinicalTrials) | ||||
| Polyclinique Bordeaux Nord Aquitaine - 33300 - Boucher - France | Contact (sur clinicalTrials) | ||||
| Polyclinique De Courlancy - F-51100 - Reims - France | Contact (sur clinicalTrials) | ||||
| Polyclinique Du Parc Centre Maurice Tubiana - 14052 - Caen - France | Contact (sur clinicalTrials) | ||||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| C. H. De Saumur - 49403 - Saumur - France | Contact (sur clinicalTrials) | ||||
| C. H. Du Mans - 72037 - Le Mans - France | Contact (sur clinicalTrials) | ||||
| C.H. Du Havre - F-76290 - Montivilliers - France | Contact (sur clinicalTrials) | ||||
| C.H.G Laval - 53024 - Laval - France | Contact (sur clinicalTrials) | ||||
| Centre d'Oncologie et de Radiotherapie de Chaumont le Bois - 52000 - Chaumont - France | Contact (sur clinicalTrials) | ||||
| Centre Hospitalier Chateaudun - 28200 - Chateaudun - France | Contact (sur clinicalTrials) | ||||
| Centre Hospitalier de Valenciennes - 59300 - Valenciennes - France | Contact (sur clinicalTrials) | ||||
| Centre Hospitalier De Vernon - 27200 - Vernon - France | Contact (sur clinicalTrials) | ||||
| Centre Hospitalier D'Evreux - 27000 - Evreux - France | Contact (sur clinicalTrials) | ||||
| Centre Hospitalier General - 72037 - Le Mans - France | Contact (sur clinicalTrials) | ||||
| Centre Rene Huguenin - 92211 - Saint Cloud - France | Contact (sur clinicalTrials) | ||||
| Clinique Armoricaine De Radiologie - F-22015 - Saint Brieuc - France | Contact (sur clinicalTrials) | ||||
| Clinique Clementville - Montpellier - France | Contact (sur clinicalTrials) | ||||
| Clinique de le Louviere - F-59800 - Lille - France | Contact (sur clinicalTrials) | ||||
| Clinique de l'Union - 31240 - Saint Jean - France | Contact (sur clinicalTrials) | ||||
| Clinique De Valdegour - 30900 - Nimes - France | Contact (sur clinicalTrials) | ||||
| Clinique du Pont de Chaume - 82017 - Montauban - France | Contact (sur clinicalTrials) | ||||
| Clinique les Bleuets - 51100 - Reims - France | Contact (sur clinicalTrials) | ||||
| Clinique Medico Chirurgicale Teissier Groupe - Valenciennes - France | Contact (sur clinicalTrials) | ||||
| Clinique Tivoli - F-33000 - Bordeaux - France | Contact (sur clinicalTrials) | ||||
| Groupe Medical St. Remy - 51100 - Reims - France | Contact (sur clinicalTrials) | ||||
| Hopital Duffaut - 84902 - Avignon - France | Contact (sur clinicalTrials) | ||||
| Medipole Gentilly Saint-Jacques - 54320 - Maxeville - France | Contact (sur clinicalTrials) | ||||
| Polyclinique de L'Ormeau - 65000 - Tarbes - France | Contact (sur clinicalTrials) | ||||
| Polyclinique Saint - Roch - 34000 - Montpellier - France | Contact (sur clinicalTrials) | ||||
Critères
Tous
DISEASE CHARACTERISTICS:
- Histologically confirmed non-small cell lung cancer
- Stage II or III disease
- Not amenable to surgery
- Measurable or evaluable disease
- No T4 apical localization
- Lesions able to be covered in a 60 Gy minimum volume of radiation
- No pleural effusion
PATIENT CHARACTERISTICS:
Age
- 18 to 79
Performance status
- ECOG 0-2
Life expectancy
- More than 3 months
Hematopoietic
- Absolute neutrophil count > 1,500/mm^3
- Platelet count > 100,000/mm^3
Hepatic
- Bilirubin < 1.5 times upper limit of normal (ULN)
Renal
- Creatinine < 1.25 times ULN
Cardiovascular
- No unstable heart disease
Pulmonary
- No ventilation dysfunction that would preclude radiotherapy
Other
- No weight loss of 15% or more within the past 2 months
- No uncontrolled infection
- No other prior malignancy except curatively treated basal cell skin cancer or
carcinoma in situ of the cervix
PRIOR CONCURRENT THERAPY:
Biologic therapy
- Not specified
Chemotherapy
- More than 6 months since prior neoadjuvant chemotherapy
- No prior adjuvant chemotherapy
Endocrine therapy
- Not specified
Radiotherapy
- See Disease Characteristics
- No prior radiotherapy
Surgery
- Not specified
Other
- No other concurrent clinical trial participation
- Histologically confirmed non-small cell lung cancer
- Stage II or III disease
- Not amenable to surgery
- Measurable or evaluable disease
- No T4 apical localization
- Lesions able to be covered in a 60 Gy minimum volume of radiation
- No pleural effusion
PATIENT CHARACTERISTICS:
Age
- 18 to 79
Performance status
- ECOG 0-2
Life expectancy
- More than 3 months
Hematopoietic
- Absolute neutrophil count > 1,500/mm^3
- Platelet count > 100,000/mm^3
Hepatic
- Bilirubin < 1.5 times upper limit of normal (ULN)
Renal
- Creatinine < 1.25 times ULN
Cardiovascular
- No unstable heart disease
Pulmonary
- No ventilation dysfunction that would preclude radiotherapy
Other
- No weight loss of 15% or more within the past 2 months
- No uncontrolled infection
- No other prior malignancy except curatively treated basal cell skin cancer or
carcinoma in situ of the cervix
PRIOR CONCURRENT THERAPY:
Biologic therapy
- Not specified
Chemotherapy
- More than 6 months since prior neoadjuvant chemotherapy
- No prior adjuvant chemotherapy
Endocrine therapy
- Not specified
Radiotherapy
- See Disease Characteristics
- No prior radiotherapy
Surgery
- Not specified
Other
- No other concurrent clinical trial participation