Informations générales (source: ClinicalTrials.gov)
Functional and Molecular Characterisation of Oesophageal Distal Epithelium: Correlations With Acid and Non Acid Reflux
Observational
Nantes University Hospital (Voir sur ClinicalTrials)
29 juin 2024
This study aims to characterize the permeability as well as some protein involved in the
cell junction in the oesophageal epithelium in patients with GORD symptoms. In addition
these patients will be characterized for their reflux especially by pH-impedancemetry,
Bilitec and oesophageal acid perfusion test. Correlations between the characteristics of
the reflux and the biological results will be calculated.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| Nantes University Hospital - 44093 - Nantes - France | Stanislas Bruley des Varannes, MD | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
Main inclusion criteria :
- Digestive symptoms suggestive of GORD (heartburn, regurgitation, epigastric pain),
or dyspeptic syndrome (nausea, belch, bloating, epigastric discomfort).
- Need of upper GI endoscopy and pH monitoring.
- Normal propagation of oesophageal persitaltic waves (manometry < 6 months).
- Age 18 -70 yrs
- Signed informed consent
- Normal coagulation
Main inclusion criteria :
- Digestive symptoms suggestive of GORD (heartburn, regurgitation, epigastric pain),
or dyspeptic syndrome (nausea, belch, bloating, epigastric discomfort).
- Need of upper GI endoscopy and pH monitoring.
- Normal propagation of oesophageal persitaltic waves (manometry < 6 months).
- Age 18 -70 yrs
- Signed informed consent
- Normal coagulation
- Barrett's oesophagus
- Previous oesophageal bleeding
- Need of NSAID treatment.
- Previous sus mesocolic surgery
- Alcool consumption > 40g/d, smoking > 10 cig/j
- Pregnancy or lack of contraceptive disposal, breast feeding.
- Allergy to Xylocaïne