Informations générales (source: ClinicalTrials.gov)
Chromogranin-A-Derived Peptides in the Gingival Crevicular Fluid and the Saliva of Diabetic Patients With or Without Periodontitis
Interventional
N/A
University Hospital, Strasbourg, France (Voir sur ClinicalTrials)
mars 2008
29 juin 2024
Periodontitis is a chronic disease of the supporting tissue of the teeth, characterized
by bleeding and inflamed gingival, resorption of alveolar bone. This disease has a
significant impact of the quality of life as the teeth become progressively mobile and
may fall out spontaneously if no treatment is provided. Periodontal disease has been
cited as the sixth complication of diabetes mellitus.Chromogranins / secretogranins are a
family of proteins present in nervous endocrine and immune cells, released with
catecholamines during stress situations. Chromogranin A (CGA) is the major member of this
family.The aim of this study is to determine the level of CGA and its derived peptides in
the gingival crevicular fluid (GCF) of health or diabetic patients with and without
periodontitis.Then, we want to determine the antimicrobial activity of these peptides.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| Département de Parodontologie - Hôpital Civil - 67091 - Strasbourg - France | Martine Soell, MD | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion criteria:
- Patients from 20 to 80 years old
- A minimum of 10 teeth
- Healthy volunteers or diabetic patients with or without periodontitis
- Patients from 20 to 80 years old
- A minimum of 10 teeth
- Healthy volunteers or diabetic patients with or without periodontitis
- a course of antibiotics
- a fungicidal therapy
- a corticotherapy
- a hormone therapy
- a pregnancy
- persons under guardianship