Informations générales (source: ClinicalTrials.gov)
Prevention of Graft Reinfection After Liver Transplantation for HCV Related End-stage Liver Disease . Study of Humoral Anti-HCV Response
Observational
University Hospital, Strasbourg, France (Voir sur ClinicalTrials)
février 2008
décembre 2015
29 juin 2024
End stage HCV-related cirrhosis has become a major indication for liver transplantation
(LT). Unfortunately, recurrence of HCV infection on the liver graft occurs in almost all
patients following transplantation and causes a persistent infection that leads to
chronic hepatitis and cirrhosis in a significant proportion of patients. To date there is
no effective way to prevent HCV reinfection of the liver graft in the early phase after
transplantation. . Early passive immunotherapy with neutralizing antibodies against HCV
should be considered for preventing reinfection of liver transplanted patients associated
with HCV. This approach is well established in the case of patients undergoing liver
transplantation for chronic hepatitis B virus infection. Our purpose is to produce
neutralizing monoclonal antibodies to prevent reinfection of the liver graft.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| Service d'Hématologie et Oncologie - Hôpital de Hautepierre - Strasbourg - France | Albert FARADJI, MD | Contact (sur clinicalTrials) | |||
| Service d'Hépato-Gastro-Entérologie - Hôpital Civil - 67000 - Strasbourg - France | Michel DOFFOEL, MD | Contact (sur clinicalTrials) | |||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Service de Chirurgie Générale et Transplantation Multiorganes - Hôpital de Hautepierre - Strasbourg - France | Philippe WOLF, MD | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Health insurance
- Resolved HCV infection ( HCV RNA negative since more then 6 months ) -HCV
chronically infected ( RNA positive )
- Anti- HCV antibodies positive
- Volunteers and informed patients
- Health insurance
- Resolved HCV infection ( HCV RNA negative since more then 6 months ) -HCV
chronically infected ( RNA positive )
- Anti- HCV antibodies positive
- Volunteers and informed patients
- Immunosuppression
- HBV or HIV infection
- Pregnancy
- Breast feeding