Informations générales (source: ClinicalTrials.gov)
Glucose Tolerance in Patients With an Idiopathic Parkinson's Disease
Interventional
N/A
University Hospital, Clermont-Ferrand (Voir sur ClinicalTrials)
mai 2010
décembre 2013
29 juin 2024
Dysfunction of autonomic nervous system is an important non motor feature of Parkinson'
disease (PD). Lewy body formation is widely distributed in hypothalamus and in
sympathetic and parasympathetic systems. Animal studies suggest a link between
hypothalamus sensing of substrates and glucose metabolism. Thus, hypothalamus lesions
could lead to change in glucose metabolism. Recently, we showed that fasting blood
glucose level was significantly higher in PD patients than in control group suggesting
that glucose tolerance may be impaired in PD. Some studies provided evidence for higher
diabetes prevalence in PD patients whereas others showed no difference or a reduced risk
of diabetes prevalence in PD patients compared to healthy subjects.
So, the risk that a PD patient develops a glucose intolerance or a diabetes is not
clearly established and merit to be studied considering the damageable consequences for
patient healthy.
The aim of this prospective study was to determine the risk that a PD patient develop a
glucose intolerance or a diabetes compared to a matched control group, using an oral
glucose tolerance test (OGTT).
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CHU Clermont-Ferrand - 63003 - Clermont-Ferrand - France | Patrick LACARIN | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Age : 18-70 years
- Patient with an idiopathic Parkinson's disease according to the criteria of the
"Parkinson's Disease Society Brain Bank" with a duration of disease >5years
- MMS>24/30
- No treatment modification 7 days before the inclusion
- Affiliation to social security
- Agreement of patients
- Age : 18-70 years
- Patient with an idiopathic Parkinson's disease according to the criteria of the
"Parkinson's Disease Society Brain Bank" with a duration of disease >5years
- MMS>24/30
- No treatment modification 7 days before the inclusion
- Affiliation to social security
- Agreement of patients
- Patient treated with antibiotics, AINS, AIS or other treatment which could interfere
with the protocol
- Patients with significant heart, respiratory, psychiatric, metabolic, hepatic,
kidney diseases; diabetes, heart deficiency, chronic kidney deficiency, untreated
thyroid disease ...
- Patient treated with a deep brain stimulation
- Patients with metabolic and/or biological anomalies
- Pregnant women
- Medical or chirurgical previous history which could interfere with the protocol
- Alcohol (>30g/day); Tobacco (>10 cigarettes/day)
- Participation to an other study at the same time