Informations générales (source: ClinicalTrials.gov)

NCT01151826 Statut inconnu
Measurement of Physical and Biochemical Markers of Reperfusion Edema During Primary Graft Dysfunction Following Lung Transplantation. Assessment of Their Diagnosis and Prognosis Values
Observational
  • Dysfonction primaire du greffon
University Hospital, Strasbourg, France (Voir sur ClinicalTrials)
juillet 2010
août 2012
29 juin 2024
Primary graft dysfunction (PGD or lung reperfusion edema) complicates 10 to 20% of lung transplantations and leads to severe early and late postoperative complications. Its pathophysiology remains unclear but may involve graft ischemia-reperfusion, increased vascular permeability, pneumocyte dysfunction and finally alveolar flooding that impair gas exchange and blood oxygenation.Its substrate, namely extravascular lung water (EVLW), can now be clinically measured with minimally invasive Intensive Care Unit monitors (PiCCO2®, Pulsion Medical Systems) that also provides a physical estimate of pulmonary vascular permeability (PVPI). Similarly, biochemical correlates of vascular permeability (ICAM-1) and pneumocyte dysfunction (RAGE) can now be measured in plasma samples. Our study aims at quantifying physical and biochemical markers of PGD and assess their diagnosis and prognosis values.
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Etablissements

Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données
Service de Chirurgie thoracique - Nouvel Hôpital Civil - 1, Place de l'hôpital - 67091 - Strasbourg Cedex - France Gilbert MASSARD, MD En recrutement Contact (sur clinicalTrials)
Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données
Service d'Anesthésie-Réanimations chirurgicales - Nouvel Hôpital Civil - Hôpitaux Universitaires de Strasbourg - 67091 - Strasbourg - France Julien Pottecher, MD En recrutement Contact (sur clinicalTrials)
Service de Physiologie et d'Explorations fonctionnelles - Nouvel Hôpital Civil - 1, Place de l'hôpital - 67091 - Strasbourg Cedex - France Bernard GENY, MD En recrutement Contact (sur clinicalTrials)
Service de Pneumologie - Nouvel Hôpital Civil -1, Place de l'hôpital - 67091 - Strasbourg Cedex - France Romain KESSLER, MD En recrutement Contact (sur clinicalTrials)

Critères

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Inclusion Criteria:

- Lung transplant recipient

- Age > 18 years

- Signed informed consent

- Social security affiliation


- Age<18

- Pregnancy or lactation

- Contraindication to femoral arterial catheterization

- Patient refusal