Informations générales (source: ClinicalTrials.gov)
Médulloblastome of the Child and After-effects Cognitive: Study Anatomo-functional by IRM of the Working Memory (MEDIR)
Observational
University Hospital, Grenoble (Voir sur ClinicalTrials)
octobre 2007
juillet 2012
29 juin 2024
The medulloblastome is a tumour of the child relatively frequent usually sitting in the
cerebellum and treated by surgery, radiotherapy and chemotherapy. After the treatment,
these children present cognitive disorders and in particular disorders of the working
memory associated with a fall with the school performances. By studying a troop of 32
children, we could show that the disorders of the working memory prevail during the
handling of information presented visually and with verbal contents. However, the
specific engagement of the cerebellum in the tasks of working memory according to the
sensory method of presentation (visual or auditive) and the nature (verbal or not verbal)
of information to treat vague remainder. Moreover, the anatomical attacks associated with
these disorders remain ignored in these children. The best comprehension of the bases
anatomo-functional calculuses which underlie their cognitive deficits is essential to
develop new strategies of treatment and rehabilitation.
Objectives:
- To describe in IRMf of the common and specific networks engaged during the execution
of the tasks of working memory according to the sensory type and the nature of
information to be memorized.
- To describe in IRMf the cortical reorganizations necessary to the execution of the
mnemic tasks among patients.
- To describe in anatomical IRM and of the tensor of diffusion lesions cérébelleuses
and cerebral, cortical and subcortical associated with these disorders.
- To study the correlations radio-private clinics between data IRM and the data
neurological and neuropsychological of the children explored according to protocol
ONCORAP
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CLCC INSTITUT GUSTAVE ROUSSY | Jacques GRILL | 14/11/2023 13:32:01 | Contacter | ||
| Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| AP-HP - Hôpital Necker-Enfants Malades | Contact (sur clinicalTrials) | ||||
| CLCC INSTITUT CURIE | Contact (sur clinicalTrials) | ||||
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Institut d'Hématologie et d'Oncologie Pédiatrique - 69008 - Lyon - France | Contact (sur clinicalTrials) | ||||
| University hospital - 33076 - Bordeaux - France | Contact (sur clinicalTrials) | ||||
| University Hospital - 42055 - Saint Etienne - France | Contact (sur clinicalTrials) | ||||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| SMAEC - 69100 - Villeurbanne - France | Contact (sur clinicalTrials) | ||||
| UniversityHospitalGrenoble - 38043 - Grenoble - France | Isabelle I SCHIFF | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Old from 8 to 12 years
- Total IQ > 70 for the participation in the study and/or age développemental 7 years
minimum
- Treaties for a médulloblastome after the 6 years age in remission supplements with 6
months a minimum time compared to the end of all the treatments
- Followed within the framework of the protocol of evaluation of the mnemic and
attentionnelles after-effects
- Sensory after-effects compatible with the realization of the tasks and good
performances at the time of the preceding drive the IRM
- Absence of counter-indication to the IRM
- Absence of catch of méthylphénidate (Ritaline®) for the treatment of disorders
attentionnels 48h before the IRM
- Enlightened assent signed by at least one of the two parents or holders of the
parental authority and by the child (minor)
- Old from 8 to 12 years
- Total IQ > 70 for the participation in the study and/or age développemental 7 years
minimum
- Treaties for a médulloblastome after the 6 years age in remission supplements with 6
months a minimum time compared to the end of all the treatments
- Followed within the framework of the protocol of evaluation of the mnemic and
attentionnelles after-effects
- Sensory after-effects compatible with the realization of the tasks and good
performances at the time of the preceding drive the IRM
- Absence of counter-indication to the IRM
- Absence of catch of méthylphénidate (Ritaline®) for the treatment of disorders
attentionnels 48h before the IRM
- Enlightened assent signed by at least one of the two parents or holders of the
parental authority and by the child (minor)
- Agitation or movements of the head at the time the IRM
- Artifacts of magnetic susceptibility in projection of the areas of interest
(intracranial haemorrhage, cortical and/or metal remains post-operative) • Bad
execution of the cognitive tasks
- Tumoral relapse in the course of protocol