Informations générales (source: ClinicalTrials.gov)
Metabolic Impact of the Digestion of Fat in Emulsified vs Non-emulsified Form in Lean or Obese Volunteers (LIPINFLOX)
Interventional
N/A
Hospices Civils de Lyon (Voir sur ClinicalTrials)
mars 2010
février 2013
29 juin 2024
In this study, the investigators are interested in investigating how the emulsification
state and amount of fat in a meal can modify the kinetics of postprandial lipemia and
inflammatory outcomes (including endotoxemia) in obese vs lean subjects.
10 lean and 10 obese volunteers will come 3 times (>3 weeks apart) at the investigation
center to receive a standard breakfast containing milk fat (10 g non emulsified, or 40 g
non emulsified, or 40 g finely emulsified). 13C triglyceride stable isotopes will allow
to follow the metabolic fate of fatty acids and calculate lipid oxidation by breath test.
Blood sampling throughout digestion will allow to measure metabolic, lipid and
inflammation parameters. Stool will be analysed to determine lipid losses in faeces and
to phenotype microbiota.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| Hospices Civils de Lyon,Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA) - 69495 Pierre Bénite Cedex - Lyon - 165 chemin du Grand Revoyet - France | Stéphanie Lambert-Porcheron, Dr. | Contact (sur clinicalTrials) | |||
Critères
Homme
Inclusion Criteria:
- No smokers
- BMI 18 to 35 kg/m2
- Moderate physical activity
- Safety subject during medical consultation
- No smokers
- BMI 18 to 35 kg/m2
- Moderate physical activity
- Safety subject during medical consultation
- Medical history which may affect lipid metabolism and gut microflora (renal
-cardiovascular -hepatic- endocrine-inflammatory diseases)
- Drug use that could affect lipid metabolism and gut microflora (steroids,
antilipemic agent, anorectic, antibiotic)
- Inflammatory or infectious disease in the last three month
- C Reactive Protein > 20
- Prebiotic or probiotic high consumers (several times a day)
- Eating disorder
- Claustrophobic subjects