Informations générales (source: ClinicalTrials.gov)
Do Facial Expression Recognition Disorder and Mirror Neurons Subtend Apathy in Parkinson's Disease?
Interventional
N/A
University Hospital, Clermont-Ferrand (Voir sur ClinicalTrials)
juillet 2010
juillet 2013
29 juin 2024
After few years of evolution, patients with Parkinson's disease may develop apathy, with
different degrees of severity. Apathy is characterized by a loss of interest for the
others and for activities. The lack of social interactions in these patients may be due
to an impairment in decoding emotional facial expression. Indeed, facial expression
recognition, which is necessary to understand other's emotional state, requires a
subclinical facial mimicking of the expression observed. Yet, one of the clinical signs
of PD is amimia.
This study aims to determinate if there is a facial mimicry disorder in PD ( Parkinson's
disease )patients with emotional facial expression (EFE) recognition impairment, compared
to healthy control subjects. We also want to know if this facial mimicry disorder is
primary (subtended by facial mobility impairment, that is to say amimia) or secondary
(related to the mirror neuron systems that allows us to activate similar neural networks
when observing and feeling a specific emotion)
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CHU Clermont-Ferrand - 63003 - Clermont-FERRAND - France | Patrick LACARIN | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Patients with idiopathic Parkinson's disease according to UKPDSBB criteria - Men or
women aged between 18 to 75 years
- Free from any visio-perceptive disorder (visual acuity and Vitec)
- Affiliated to National Health system
- Having given their informed consent
--Healthy controls
- Men or women aged between 18 to 75 years
- Free from any visio-perceptive disorder (visual acuity and Vitec)
- Affiliated to National Health system
- Having given their informed consent
- Patients with idiopathic Parkinson's disease according to UKPDSBB criteria - Men or
women aged between 18 to 75 years
- Free from any visio-perceptive disorder (visual acuity and Vitec)
- Affiliated to National Health system
- Having given their informed consent
--Healthy controls
- Men or women aged between 18 to 75 years
- Free from any visio-perceptive disorder (visual acuity and Vitec)
- Affiliated to National Health system
- Having given their informed consent
- With dementia or with significant dysexecutive disorder (MMS <24, MATTIS< 130)
- With fluctuations (<5 Levodopa intakes / day)
- With severe depression (BDI > 27)
- With psychiatric comorbidities (hallucinations, psychos) evaluated with l'Unified
Parkinson's disease Rating Scale part I (UPDRS part I =0)
- With faces processing disorder (Benton < 39)
- Pregnant
- Treatment with deep brain stimulation
- Under guardianship
- In excluding period for another study
--Healthy controls
- Suffering of neurological or psychiatric evolutive condition
- With severe depression (BDI > 27)
- With faces processing disorder (Benton < 39)
- Pregnant
- In excluding period for another study