Informations générales (source: ClinicalTrials.gov)
Effect of the Correction of Vitamin D Deficiency in Patients With Obstructive Sleep Apnea-hypopopnea Syndrome (OSAHS)
Interventional
Phase 2
University Hospital, Clermont-Ferrand (Voir sur ClinicalTrials)
mars 2011
juin 2012
29 juin 2024
Obstructive sleep apnea/hypopnea syndrome (OSAHS) is a highly prevalent disorder with
multiple comorbidities.
OSAHS is characterized by repetitive episodes of airflow reduction (hypopnoea) or
cessation (apnoea) due to upper airway collapse during sleep. Its major risk factor is
obesity. However, its pathogenesis is complex and multifactorial. Reduced upper airway
muscle tonus and/or unstable neuromuscular output seem to be involved in this collapsus.
A normal vitamin D status is necessary for normal muscle function and neuromuscular
output. As obesity is associated with a high rate of hypovitaminosis D, it appears of
interest to evaluate the effect of vitamin D supplementation on OSAHS patients with
vitamin D deficiency.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CHU Clermont-Ferrand - 63003 - Clermont-Ferrand - France | Patrick LACARIN | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Moderate to severe obstructive sleep apnoea (AHI > 15)
- With or without continuous positive airway pressure for a minimum of six months
- aged 30-75 years
- Vitamin D2D3 level < 30 ng/ml
- Moderate to severe obstructive sleep apnoea (AHI > 15)
- With or without continuous positive airway pressure for a minimum of six months
- aged 30-75 years
- Vitamin D2D3 level < 30 ng/ml
- Diseases or therapy known to interfere with phospho-calcium or vitamin D metabolism
- Patients with mixed sleep apnoea (central and obstructive)
- Patients with CPAP use < 4 hours per night
- Patients with maxillofacial or oro-pharyngeal diseases)
- Patients with chronic respiratory failure, hypercapnic patients
- Muscle diseases
- Alcohol intake > 2 glasses per day
- Body mass index > 40 kg/m2