Informations générales (source: ClinicalTrials.gov)
Cerebral Substrates of Prospective Memory in Healthy Young Adults and Disruptions in Normal Aging and Alzheimer Disease: a Study in Anatomical, Functional and Diffusion Tensor MRI. (IMPRO)
Interventional
N/A
University Hospital, Caen (Voir sur ClinicalTrials)
septembre 2010
juin 2015
29 juin 2024
The purpose of this study is to investigate prospective merory (memory of intentions) in
healthy controls and in aMCI (amnestic Mild Cognitive Impairment) and AD (Alzheimer
Disease) patients.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| GIP Cyceron - 14000 - Caen - Calvados - France | Contact (sur clinicalTrials) | ||||
| University Hospital Côte de Nacre - 14033 - Caen - France | Contact (sur clinicalTrials) | ||||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| MRSH - University of Caen - 14000 - Caen - Calvados - France | Contact (sur clinicalTrials) | ||||
Critères
Tous
Inclusion Criteria :
- Education level > 7 years
- Native language: French
- Beck < 7
- Medical, neurological, neuropsychological and neuroradiological depth in accordance
with the criteria for inclusion and exclusion-specific population, that is to say:
- Young Healthy Subjects: between 18 and 44 years old;
- Middle age Healthy Subjects: between 45 and 69 years old; without memory
complaints, normal performances compared to the age and the educational level
for all tests of the diagnostic battery.
- Elderly Healthy Subjects: over 70 years old, without memory complaints, normal
performances compared to the age and the educational level for all tests of the
diagnostic battery.
- MCI patients: over 50 years old, presenting the current criteria for amnestic
MCI including: i) memory complaint, ii) deficits of the episodic memory (lower
performance of at least 1 SD from the norm for age and cultural level for one
or more scores of episodic memory and iii) normal performances compared to the
age and the educational level of all other cognitive functions as memory,
including tests to assess cognitive abilities.
- Alzheimer's patients: over 50 years old, presenting the standard criteria of
NINCDS-ADRDA probable Alzheimer's disease, including abnormal global cognitive
function and deficits in at least two cognitive domains identified by the
diagnostic battery and a mild to moderate Alzheimer's disease (MMSE ≥ 18).
Exclusion Criteria :
- The sudden onset of cognitive impairments (as opposed to their slow and gradual
installation in Alzheimer's disease)
- A chronic neurological, psychiatric, endocrine, hepatic or infectious complaint
- A history of major disease (a lung, heart, metabolic, hematologic, endocrine disease
or a severe cancer);
- A medication that may interfere with memory or metabolic measures
- A alcohol or drugs abuse
- claustrophobia, metallic object in the body
- A predominantly left-hand (score below 50% in Edinburgh Inventory).
- Protected adults, and persons not affiliated with a social security system will not
participate in this study.
- Pregnant or suckling women
- The inclusion of a participant in another biomedical research protocol (during the
study or within 12 months before inclusion)
- Education level > 7 years
- Native language: French
- Beck < 7
- Medical, neurological, neuropsychological and neuroradiological depth in accordance
with the criteria for inclusion and exclusion-specific population, that is to say:
- Young Healthy Subjects: between 18 and 44 years old;
- Middle age Healthy Subjects: between 45 and 69 years old; without memory
complaints, normal performances compared to the age and the educational level
for all tests of the diagnostic battery.
- Elderly Healthy Subjects: over 70 years old, without memory complaints, normal
performances compared to the age and the educational level for all tests of the
diagnostic battery.
- MCI patients: over 50 years old, presenting the current criteria for amnestic
MCI including: i) memory complaint, ii) deficits of the episodic memory (lower
performance of at least 1 SD from the norm for age and cultural level for one
or more scores of episodic memory and iii) normal performances compared to the
age and the educational level of all other cognitive functions as memory,
including tests to assess cognitive abilities.
- Alzheimer's patients: over 50 years old, presenting the standard criteria of
NINCDS-ADRDA probable Alzheimer's disease, including abnormal global cognitive
function and deficits in at least two cognitive domains identified by the
diagnostic battery and a mild to moderate Alzheimer's disease (MMSE ≥ 18).
Exclusion Criteria :
- The sudden onset of cognitive impairments (as opposed to their slow and gradual
installation in Alzheimer's disease)
- A chronic neurological, psychiatric, endocrine, hepatic or infectious complaint
- A history of major disease (a lung, heart, metabolic, hematologic, endocrine disease
or a severe cancer);
- A medication that may interfere with memory or metabolic measures
- A alcohol or drugs abuse
- claustrophobia, metallic object in the body
- A predominantly left-hand (score below 50% in Edinburgh Inventory).
- Protected adults, and persons not affiliated with a social security system will not
participate in this study.
- Pregnant or suckling women
- The inclusion of a participant in another biomedical research protocol (during the
study or within 12 months before inclusion)