Informations générales (source: ClinicalTrials.gov)

NCT01763853 Statut inconnu
Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) (IROCA)
Interventional
  • Oedème
  • Oedème pulmonaire
  • Syndrome de détresse respiratoire du nouveau-né
  • Syndrome de détresse respiratoire de l'adulte
  • Syndrome
  • Hypovolémie
  • Lésion pulmonaire aigüe
Phase 4
University Hospital, Clermont-Ferrand (Voir sur ClinicalTrials)
décembre 2012
mai 2017
29 juin 2024
The need for fluid resuscitation (FR) in ICU patients with acute respiratory distress syndrome (ARDS) is common. Indeed, relative or absolute hypovolemia is a common phenomenon that the intensivist must recognize early and treat promptly. Fluid challenge may have adverse side effects associated with fluid administration. The diffusion within the interstitial space may favor edema formation and cause cardiac dysfunction by volume overload. Edema formation is global and may specifically alter pulmonary alveolar epithelial integrity, leading to enhanced alveolar edema and impaired gas exchange. Currently, two types of fluids are frequently used, crystalloids and colloids. Among colloids and compared to crystalloids, albumin has the theoretical advantage of causing greater volume expansion. We hypothesized that a fluid resuscitation therapy with albumin generates less pulmonary edema than a fluid resuscitation therapy with crystalloids. The aim of our study is to compare alveolar fluid clearance, as a marker of alveolar edema fluid resorption, in 2 groups of patients: those treated with albumin and those treated with crystalloid.
 Voir le détail

Etablissements

Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données
CHU Clermont-Ferrand - 63003 - Clermont-Ferrand - France Patrick Lacarin En recrutement Contact (sur clinicalTrials)

Critères

Tous
Inclusion Criteria:

- ICU patients under mechanical ventilation

- Patients within the first 24 hours after onset of moderate or severe ARDS, as
defined by the Berlin definition (JAMA. 2012;307(23):2526-2533)

- Hypovolemia requiring fluid resuscitation therapy


- Pregnancy

- Age under 18

- Refusal of the protocol

- Contraindications for the use of Voluven© or Ringer Lactate©

- Contraindications for femoral artery catheterization or subclavian venous
catheterization