Informations générales (source: ClinicalTrials.gov)
Identification of Genetic and Cellular Markers Associated With Vascular Endothelial Modifications in Cutaneous Arteriovenous Malformations
Interventional
N/A
Assistance Publique Hopitaux De Marseille (Voir sur ClinicalTrials)
janvier 2013
juillet 2016
29 juin 2024
Cutaneous Arteriovenous malformations (AVM's) rare congenital high-flow vascular
malformations in which arteries and veins are directly connected through a complex web of
abnormal arteries and veins instead of a normal capillary network. Arterial feeders and
enlarged draining veins directly connect through arteriovenous fistulas that create the
"nidus". The natural history of AVMs is organized into a clinical staging system: during
the first phase of quiescence, the arteriovenous malformation mimics a capillary
malformation. After many years, the AVM may enlarge with loco-regional expansion and
tissular destruction. At the ultimate stage, AVM may impact the heart function. They are
considered non malignant but can expand and become a significant clinical risk when
extensive. The management of these high flow AVM remains often problematic. Complete and
large surgical excision of the nidus after hyperselective embolization is the only
potential therapeutic solution but this, is often difficult if not impossible. There is
no pathogenetic hypothesis for the development of these malformations. Histopathological
examination (performed only on surgical resection specimen) is poor and does not provide
sufficient evidence to assess the evolutivity or the severity of the MAV. Recent data
hypothesize that these vascular malformations are associated with alterations of the
vascular endothelium caused by genetic abnormalities involved in the control of
angiogenesis and vascular homeostasis. The detection of these anomalies allows the search
for cellular and genetic markers that might be useful to optimize the clinical
classification, staging, predicting the evolution of these defects and some understanding
of its pathophysiological mechanisms. To our knowledge, no studies to identify cellular
markers / genetic and endothelial associated with the development of cutaneous AVMs have
been published to date.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| Assistance Publique Hopitaux de Marseille - 13006 - Marseille - France | nathalie degardin | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Male or feminine Subject
- Subject of 10 and more years old,
- Subject weighing more than 55 kg. patients:
- Subject presenting a cutaneous artério-venous deformation there outside of any other
deformation or known vascular tumor.
- Subject presenting no other susceptible pathology to influence endothéliaux markers
(Renal insufficiency, inflammatory pathology chronicles, infections, pathologies
cardiovascular, diabetes, evolutionary tumoral pathology).
volunteers:
- Unhurt Subject of deformation or vascular tumor.
- Subject presenting no other susceptible pathology to influence endothéliaux
markers(scorers) (Renal insufficiency, inflammatory pathology chronicles,
infections, pathologies cardiovascular).
- Male or feminine Subject
- Subject of 10 and more years old,
- Subject weighing more than 55 kg. patients:
- Subject presenting a cutaneous artério-venous deformation there outside of any other
deformation or known vascular tumor.
- Subject presenting no other susceptible pathology to influence endothéliaux markers
(Renal insufficiency, inflammatory pathology chronicles, infections, pathologies
cardiovascular, diabetes, evolutionary tumoral pathology).
volunteers:
- Unhurt Subject of deformation or vascular tumor.
- Subject presenting no other susceptible pathology to influence endothéliaux
markers(scorers) (Renal insufficiency, inflammatory pathology chronicles,
infections, pathologies cardiovascular).
- Subject of less than 10 years old
- Subject weighing less than 55 kg
- Subject presenting another type(chap) of vascular vascular deformation or tumor