Informations générales (source: ClinicalTrials.gov)
Consumption of Fatty Acids, Metabolism of Adipose Tissue and Risk of Colorectal Cancer: AGARIC Case Control Study (AGARIC)
Interventional
N/A
Centre Hospitalier Universitaire Dijon (Voir sur ClinicalTrials)
29 juin 2024
The aim of the study is to establish the existence of a relationship between the dietary
intake of polyunsaturated fatty acids (PUFA) and the risk of colorectal cancer in humans,
using 2 reliable and complementary biomarkers: the fatty acid-composition of lipids of
the abdominal subcutaneous adipose tissue and the fatty acid composition of erythrocyte
phospholipids.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CHU Dijon - 21079 - Dijon - France | Patrick RAT | Contact (sur clinicalTrials) | |||
| CHU Jean Minjoz - 25030 - Besancon - France | Georges MANTION | Contact (sur clinicalTrials) | |||
| Hôpital de BRABOIS - 54511 - Vandoeuvre-les-nancy - France | Laurent BRESLER | Contact (sur clinicalTrials) | |||
| Hôpital Robert Debré - 51092 - Reims - France | Jean-François DELATTRE | Contact (sur clinicalTrials) | |||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Hôpital Hautepierre - 67200 - Strasbourg - France | Serge ROHR | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
CASES
- Patients aged ≥ 45 years
- with a first recently-diagnosed colorectal cancer
- due to undergo elective surgical resection with curative intent (in practice, stage
I, II, III or IV if there was only one hepatic nodule that was resected with
curative intent) in one of the 5 following digestive surgery units: CHU de Dijon,
CHU de Nancy, CHU de Strasbourg, CHU de Reims et CHU and Besançon.
- who have given their informed consent
CONTROLS
- Patients aged ≥ 45 years
- due to undergo surgery for a benign abdominal disease (sigmoid diverticulitis,
appendectomy, hiatal hernia ...)
- matched for abdominal site with cases for age (± 3 years), sex and hospital
- Who have given their informed consent
CASES
- Patients aged ≥ 45 years
- with a first recently-diagnosed colorectal cancer
- due to undergo elective surgical resection with curative intent (in practice, stage
I, II, III or IV if there was only one hepatic nodule that was resected with
curative intent) in one of the 5 following digestive surgery units: CHU de Dijon,
CHU de Nancy, CHU de Strasbourg, CHU de Reims et CHU and Besançon.
- who have given their informed consent
CONTROLS
- Patients aged ≥ 45 years
- due to undergo surgery for a benign abdominal disease (sigmoid diverticulitis,
appendectomy, hiatal hernia ...)
- matched for abdominal site with cases for age (± 3 years), sex and hospital
- Who have given their informed consent
CASES
- pre-operative anticancer treatment (chemo or radiotherapy)
- existence of visceral metastases except a single hepatic nodule resected with
curative intent
- familial adenomatous polyposis and HNPCC syndrome (when suspected: inclusion after
complementary tumor phenotype study: screening for microsatellite instability and/or
immunohistochemistry study of the expression of DNA mismatch repair proteins.
- known inflammatory disease of the intestine (ulcerative colitis, Crohn's disease)
- personal history (recent or not) of colorectal cancer
- emergency treatment for the presenting complication (perforation, occlusion...)
- significant modification in dietary habits during the previous three months
- other evolving neoplastic disease
- psychic state incompatible with understanding the modalities and the aims of the
study (notably patients under guardianship)
- pregnant or breast-feeding women
CONTROLS
- personal history of cancer or adenomatous colorectal polyps,
- emergency intervention
- known inflammatory disease of the intestine (ulcerative colitis, Crohn's disease)
- personal history (recent or not) of colorectal cancer
- emergency treatment for the presenting complication (perforation, occlusion...)
- significant modification in dietary habits during the previous three months
- evolving neoplastic disease
- psychic state incompatible with understanding the modalities and the aims of the
study (notably patients under guardianship)
- pregnant or breast-feeding women