Informations générales (source: ClinicalTrials.gov)
Phenotype/Genotype Correlation in a Family With Early Onset Osteoarthritis: Contribution of Genetic in the Diagnosis and Early Management of Patients. (Exorhum)
Observational
University Hospital, Caen (Voir sur ClinicalTrials)
décembre 2013
décembre 2018
29 juin 2024
This study will investigate the genes responsible for osteoarthritis. Individuals with
osteoarthritis known or suspected to be caused by a gene mutation (change) may be
eligible for this study. Family members may also participate.
Patients will talk with investigators who will explain the study and its possible
implications for the patient and family and answer questions. The patient's medical
records will be reviewed, a personal and family history will be taken, and a physical
examination will be done. Two procedures may be done including blood sampling (which will
be used for DNA (genetic) studies) and X-rays (to define osteoarthritis grade).
If no known mutations responsible for osteoarthritis will be detected, participating
family members will be interviewed by telephone about their personal and family health
history and will have a blood sample drawn for DNA testing, and X-rays.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CHU - 14000 - Caen - France | BAUGE | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Individuals (and family members) with early onset osteoarthritis according to the
following definition:
- symptomatic OA before 50 years old
- no obvious causes of OA (IMC > 30, dysplasia,joint traumas)
- at least three OA locations
- Individuals (and family members) with early onset osteoarthritis according to the
following definition:
- symptomatic OA before 50 years old
- no obvious causes of OA (IMC > 30, dysplasia,joint traumas)
- at least three OA locations
- Individuals younger than 18 years old.