Informations générales (source: ClinicalTrials.gov)
Single Embryo Transfer: Comparison of Slow Freezing and Vitrification at Blastocyst Stage
Interventional
N/A
University Hospital, Clermont-Ferrand (Voir sur ClinicalTrials)
février 2014
mars 2018
29 juin 2024
Improvement in the treatment of infertility by Assisted Reproductive Techniques (ART)
allows single embryo transfer to be applied without compromising pregnancy rates after
the first in vitro fertilization (IVF) or Intra Cytoplasmic Sperm Injection (ICSI)
attempt in women less than 36 years old with good embryo quality. The policy of
transferring more than one embryo after IVF or ICSI has been the main reason for the
numerous twin or triple pregnancies reported in Europe and United States over the past 15
years. These multiple pregnancies are the main disadvantage of ART because of their
negative impact on obstetrical, neonatal and economic outcome. In the past, embryos were
replaced in the uterus on either Day-2 or 3 of development at the cleavage stage. With
the development of physiologically-based sequential culture media, it has also been
suggested that extending embryo culture to Day-5 in order to transfer the embryo at the
blastocyst stage would enhance the likelihood of pregnancy. Nevertheless, it has been
observed higher pregnancy rate after the transfer of fresh blastocyst but not after the
transfer of thawed blastocyst frozen by slow freezing procedure.
However a recent embryo freezing technique (vitrification) seems to show significant
higher pregnancy rates when blastocyst are frozen by this method. To our knowledge, no
publications have reported the outcome of single embryo transfer at blastocyst stage by a
prospective randomized and comparative study including the results of fresh and
frozen/thawed blastocyst by these two methods (slow freezing vs. vitrification) in case
of single embryo transfer .
Therefore, the aim of our study is to analyze whether extended culture of Day-2 top
embryos to blastocyst-stage may improve the cumulative delivery rate in an in vitro
fertilization program with Single Embryo Transfer policy in a prospective and randomized
study integrating the transfer of fresh and frozen/thawed embryos using a slow freezing
versus vitrification procedure.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CHU de Clermont-Ferrand - 63003 - Clermont-Ferrand - France | Patrick LACARIN | Contact (sur clinicalTrials) | |||
Critères
Femme
Inclusion Criteria:
- woman < 36 years old
- first IVF or ICSI attempt with ejaculated sperm
- at least 5 ovocytes at the pick up
- at least 3 top embryos at day-2
- at least one supernumerary blastocyst with good quality at day-5 or day-6
- woman < 36 years old
- first IVF or ICSI attempt with ejaculated sperm
- at least 5 ovocytes at the pick up
- at least 3 top embryos at day-2
- at least one supernumerary blastocyst with good quality at day-5 or day-6
-
- woman : FSH >12UI/l
- ICSI with epididymal or testicular spermatozoa
- None supernumerary blastocyst with good quality at day-5 or day-6
- Refuse by the couple to have an embryo transfer at day-5