Informations générales (source: ClinicalTrials.gov)

NCT02245061 Statut inconnu
Cortical Excitability Assessment of Pharmacoresistant Focal Epilepsy Using Direct Electrical Stimulation During Stereo-electroencephalography (PP)
Interventional
  • Épilepsie
  • Épilepsies partielles
N/A
Hospices Civils de Lyon (Voir sur ClinicalTrials)
septembre 2014
septembre 2021
29 juin 2024
The identification of the epileptogenic zone (EZ) during pharmacoresistant focal epilepsy presurgical assessment frequently requires intracranial recordings like stereo-electroencephalography (SEEG). Cortical direct electrical stimulation (DES) is commonly used during SEEG for functional mapping or to induce seizure. However, the recording of seizures is sometimes insufficient to circumscribe the EZ and development of new biomarkers is necessary. The cortex within the EZ is thought to be hyperexcitable. The "paired pulses" paradigm, using transcranial magnetic stimulation (TMS), allows determining the hemispheric cortical excitability level. The investigators hypothesize that paired pulses DES during SEEG could provide useful information for EZ identification.
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Etablissements

Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données
Hôpital neurologique de Lyon - 69003 - Lyon - France Sylvain RHEIMS, MD En recrutement Contact (sur clinicalTrials)

Critères

Tous
Inclusion Criteria:

- Age above 18 years old

- Pharmacoresistant focal epilepsy patients undergoing a
stereo-electroencephalographic recording

- Provide written consent to the study after receiving clear information

- Be a beneficiary or member of health insurance plan


Patient with contraindication for MRI scanning

- Pregnancy

- Prohibition on participation in other research, apart from any other
non-interventional research