Detail Article

Informations générales (source: ClinicalTrials.gov)

Numéro NCT

NCT02252900 Statut inconnu

Titre

Long-term Clinico-radiological Evolution of Patients With Symptomatic and Asymptomatic Brain Lesions During Infectious Endocarditis (POST-IMAGE)

Type

Interventional

Pathologie

Maladies transmissibles
Endocardite
Endocardite bactérienne subaigüe
Infection

Phase

N/A

Promoteur

Assistance Publique - Hôpitaux de Paris (Voir sur ClinicalTrials)

Date de début

décembre 2013

Date de fin

mars 2018

Dernière mise à jour

29 juin 2024

Résumé

Primary objective: To describe the evolution of cerebral lesions in IE patients (number of patients with abnormal cerebral MRI in acute phase of IE and during follow-up).

Détail

Voir le détail Introduction: Infectious endocarditis (IE) is a rare disease (1500 cases per year in France) with a poor prognosis (20 % of mortality). Neurological complications participate in the initial morbimortality but their long-term impact is poorly known. The acute neurological complications are symptomatic in approximately a quarter of patients. Neurological lesions are frequently observed using systematic cerebral imaging. In the IMAGE study, systematic cerebral MRI in 130 patients performed during the acute phase of IE allowed found cerebral lesion in 82 % of the patients and in 79 % of patients without neurological symptoms. The evolution of cerebral lesion, including brain micro-bleedings and their impact prognosis are not known. Hypothesis: Cerebral lesions detected by MRI during the acute phase of infectious endocarditis may involve and may have an impact on functional prognosis. Primary objective: To describe the evolution of cerebral lesions in IE patients (comparing the proportion of patients with abnormal cerebral MRI in acute phase of IE and during follow-up). Secondary objectives: - To compare frequency of different brain damages in acute phase of IE and during follow-up. - To analyse the relationship between functional and cognitive status and cerebral lesions. - To analyse the relationship between initial and follow-up cerebral lesions and initials characteristics (microorganisms, anticoagulation, echocardiographic characteristics, valve replacement surgery, type of valvular substitute, mycotic aneurysm embolization) - To collect plasma during follow-up of IE - To compare patient characteristics between patients who accept the functional exploration and those who patient refuse - To describe oral health and oral condition Fermer le détail

Etablissements

Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données
CH BICHAT MAISON BLANCHE	Bernard IUNG, Professor	En recrutement IDF		Contact (sur clinicalTrials)

Critères

Genre

Tous

Nombre d'inclusion

Critère d'inclusion

Inclusion Criteria:

- History of Infective endocarditis treated in Bichat Claude Bernard hospital

- Cerebral MRI performed during the acute phase of endocarditis

- Resident in Metropolitan France

- 18 years old or more

Critère de non inclusion

- Refusal to participate

- Contra indication to MRI scan

- History of allergy to gadolinium

- Pregnancy or lactating female

- Lack of Social Security or CMU (recipient or beneficiary)

NCT02252900 - Long-term Clinico-radiological Evolution of Patients With Symptomatic and Asymptomatic Brain Lesions During Infectious Endocarditis (POST-IMAGE)

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