Informations générales (source: ClinicalTrials.gov)
SCHIZOBAT/DEPBAT : Characterization of the Motivational Deficit in Schizophrenia and Depression (SCHIZOBAT)
Interventional
N/A
Centre Hospitalier St Anne (Voir sur ClinicalTrials)
novembre 2014
janvier 2019
29 juin 2024
This research focuses on disorders of motivation, responsible for a disability that
patients experience daily. It is a disorder that affects behavior, especially social.
Mechanisms, which result in these disorders, are poorly understood. This ignorance is
responsible for the lack of effective therapy. The investigators realize this work in
order to better understand the motivational deficits. The objective of the study is to
characterize the cognitive mechanisms of motivational deficits in schizophrenia and
depression. To answer the question posed in the research, it is planned to include 35
people with schizophrenia, 35 people with depression and 70 heathy volunteers in the
Hospital of Sainte-Anne .
Etablissements
| Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| GHU PARIS PSY ET NEUROSCIENCES | Raphaël GAILLARD, MD,PhD | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria (schizophrenia group) :
- Patients :
- Age between 18 and 65 years
- Affiliation to a healthy insurance
- Subjects who were informed and willing to sign the form of free and informed
consent and information of the curator if necessary (or consent of the tutor)
- French native tongue
- Diagnosis of schizophrenia according to ICD-10, made by a psychiatrist. The
subjects are stabilized (less than three items include a score> = 4 or to the
positive level (P) of the PANSS)
- Unchanged psychotropic treatment for at least three months before inclusion, a
minimal dose adjustment in the last month is tolerable.
- Healthy volunteers:
- Age between 18 and 65 years
- Affiliation to a healthy insurance
- Subjects who were informed and willing to sign the form of free and informed
consent and information curator appropriate
- French native tongue
Exclusion Criteria (schizophrenia group) :
- Patients:
- Unable major, persons deprived of liberty, pregnant women
- Enforced hospitalisation
- Recent abuse (1 week) or chronic use of addictive substances, except tobacco
- Treatment electro-convulsivo-therapy in the last 6 months
- Degenerative Pathology, neurological disorder
- Co-occurrence of a major depressive episode in a schizophrenic patient
evaluated by a score> 10 CDS
- Difficulty in understanding and expression in French language
- Deficit of visual acuity or uncorrected hearing
- Healthy volunteers:
- Unable major, persons deprived of liberty, pregnant women
- Current psychiatric disease
- Psychotropic treatment
- Recent abuse (1 week) or chronic use of addictive substances, except tobacco
- Difficulty in understanding and expression in French language
- Deficit of visual acuity or uncorrected hearing
- Mental retardation
Inclusion Criteria (depression group) :
- Patients :
- Age between 18 and 75 years
- Affiliation to a healthy insurance
- Subjects informing and accepting to sign the free and lit consent form and
information of the curator if necessary or consent of the tutor
- French Mother tongue
- Diagnosis of major depressive episode following the CIM-10, put by a
psychiatrist.
- Healthy volunteers:
- age between 18 and 75 years
- Affiliation to a healthy insurance
- Subjects informing and accepting to sign the free and lit consent form
- French mother tongue
Exclusion Criteria (depression group) :
- Patients
- persons deprived of liberty , pregnant women
- Admission under constraint
- Recent Abuse ( 1 week) or consumption chronicles of addicting substances,
except the tobacco
- Treatment by electroconvulsivo-therapy
- Degenerative Pathology or obvious neurological disorder
- Diagnosis of schizophrenia or disorder of personality severe
- Difficulties of understanding and expression in French language
- Uncorrected visual or hearing Deficit of acuteness
- Healthy volunteers:
- Incapable, persons deprived of liberty, pregnant women
- Recent Abuse (1 week) or consumption chronicles of addicting substances, except
tobacco
- Personal psychiatric Histories
- Current psychiatric Disorder
- Current psychotropic Treatment
- Patients :
- Age between 18 and 65 years
- Affiliation to a healthy insurance
- Subjects who were informed and willing to sign the form of free and informed
consent and information of the curator if necessary (or consent of the tutor)
- French native tongue
- Diagnosis of schizophrenia according to ICD-10, made by a psychiatrist. The
subjects are stabilized (less than three items include a score> = 4 or to the
positive level (P) of the PANSS)
- Unchanged psychotropic treatment for at least three months before inclusion, a
minimal dose adjustment in the last month is tolerable.
- Healthy volunteers:
- Age between 18 and 65 years
- Affiliation to a healthy insurance
- Subjects who were informed and willing to sign the form of free and informed
consent and information curator appropriate
- French native tongue
Exclusion Criteria (schizophrenia group) :
- Patients:
- Unable major, persons deprived of liberty, pregnant women
- Enforced hospitalisation
- Recent abuse (1 week) or chronic use of addictive substances, except tobacco
- Treatment electro-convulsivo-therapy in the last 6 months
- Degenerative Pathology, neurological disorder
- Co-occurrence of a major depressive episode in a schizophrenic patient
evaluated by a score> 10 CDS
- Difficulty in understanding and expression in French language
- Deficit of visual acuity or uncorrected hearing
- Healthy volunteers:
- Unable major, persons deprived of liberty, pregnant women
- Current psychiatric disease
- Psychotropic treatment
- Recent abuse (1 week) or chronic use of addictive substances, except tobacco
- Difficulty in understanding and expression in French language
- Deficit of visual acuity or uncorrected hearing
- Mental retardation
Inclusion Criteria (depression group) :
- Patients :
- Age between 18 and 75 years
- Affiliation to a healthy insurance
- Subjects informing and accepting to sign the free and lit consent form and
information of the curator if necessary or consent of the tutor
- French Mother tongue
- Diagnosis of major depressive episode following the CIM-10, put by a
psychiatrist.
- Healthy volunteers:
- age between 18 and 75 years
- Affiliation to a healthy insurance
- Subjects informing and accepting to sign the free and lit consent form
- French mother tongue
Exclusion Criteria (depression group) :
- Patients
- persons deprived of liberty , pregnant women
- Admission under constraint
- Recent Abuse ( 1 week) or consumption chronicles of addicting substances,
except the tobacco
- Treatment by electroconvulsivo-therapy
- Degenerative Pathology or obvious neurological disorder
- Diagnosis of schizophrenia or disorder of personality severe
- Difficulties of understanding and expression in French language
- Uncorrected visual or hearing Deficit of acuteness
- Healthy volunteers:
- Incapable, persons deprived of liberty, pregnant women
- Recent Abuse (1 week) or consumption chronicles of addicting substances, except
tobacco
- Personal psychiatric Histories
- Current psychiatric Disorder
- Current psychotropic Treatment