Informations générales (source: ClinicalTrials.gov)
Membrane Shedding During Severe Sepsis and Septic Shock: Pathophysiological and Clinical Relevance
Observational [Patient Registry]
University Hospital, Strasbourg, France (Voir sur ClinicalTrials)
mars 2013
mars 2020
29 juin 2024
Microparticules (MPs) result from plasma cell membrane remodeling and shedding after cell
stimulation or apoptosis. MPs are know recognized as a pool of bioactive messengers with
merging role in pathophysiology of immune and cardiovascular diseases. MPs have been
characterized during septic shock and may contribute to dissemination of pro-inflammatory
and procoagulant mediators. This a prospective observational study of circulating MPs and
blood coagulation in septic shock patients admitted in medical intensive care units
(ICUs) of four tertiary hospitals at baseline (D1, D2, D3, D4, D7).
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| Nouvel Hopital Civil - 67091 - Strasbourg - Alsace - France | Ferhat MEZIANI, MD, PhD | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Septic shock (patients)
- Without septic shock (control)
- Informed consent
- Septic shock (patients)
- Without septic shock (control)
- Informed consent
- Class IV heart failure
- Child-plugh grade C cirrhosis
- Cancer under active treatment
- BMI>35kg/m2
- Moribund patient
- DNR decision