Informations générales (source: ClinicalTrials.gov)

NCT02404779 Statut inconnu
Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents. A Controlled Randomized Study Versus Placebo (THIC Cu)
Interventional
  • Lésions traumatiques de l'encéphale
  • Lésions encéphaliques
  • Hypertension artérielle
  • Hypertension intracrânienne
Phase 4
University Hospital, Clermont-Ferrand (Voir sur ClinicalTrials)
mars 2015
juin 2022
29 juin 2024
Severely brain injured patients are at high risk of intracranial hypertension. Among medical treatments (sedatives), neuromuscular blocking agents (NMBA) are recommended by french but not english speaking societies. Effects of NMBA are unknown. The present study is designed to compare the effects of NMBA versus placebo in the treatment of intracranial hypertension, and the underlying physiopathologic effects.
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Etablissements

Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données
CHU de Clermont-Ferrand - 63003 - Clermont-Ferrand - France Patrick LACARIN En recrutement Contact (sur clinicalTrials)

Critères

Tous
Inclusion Criteria:

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- Age over 18

- Mechanical ventilation and deep sedation

- Severe traumatic brain injury

- Intracranial hypertension (ICP > 20 mmHg during > 15 minutes)

- Intracranial pressure monitoring

- Hemodynamically stable


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- History of anaphylaxia with neuromuscular agents

- Hemodynamic instability

- Pregnant and/or breast feeding women