Informations générales (source: ClinicalTrials.gov)
Cellular and Molecular Adaptations to Exercise-induced Inflammatory Response in Children With Autoimmune Diseases (AJI-APA)
Interventional
N/A
University Hospital, Clermont-Ferrand (Voir sur ClinicalTrials)
juillet 2015
janvier 2017
29 juin 2024
Juvenile idiopathic arthritis (JIA) is a chronic disease characterized by persistent
joint inflammation. The immune system disruption that leads to overproduction of
pro-inflammatory cytokines (TNF-α, IL-1, IL-6) is a cascade of events on different
levels-some molecular, some cellular, and some systemic. Our objective is to identify the
mechanisms through which physical activity is liable to mediate inflammatory balance in
autoimmune disease settings, and specifically in JIA patients.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CHU de Clermont-Ferrand - 63003 - Clermont-Ferrand - France | Patrick LACARIN | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Children between 8 and 12 years
- Tanner stage < T2
- polyarthritis, oligoarthritis and ERA sub-type of JIA
- Stable disease during 3 months before starting study
- Children between 8 and 12 years
- Tanner stage < T2
- polyarthritis, oligoarthritis and ERA sub-type of JIA
- Stable disease during 3 months before starting study
- Infection
- Fever
- Anti-IL6 treatment
- More than 6h per week of physical activity
- Systemic corticosteroid treatment during the 3 months before starting study
- Systemic JIA
- JIA not mastered by treatments
- Other autoimmunity or auto-inflammatory diseases
- Participation in another clinical research protocol