Informations générales (source: ClinicalTrials.gov)
(Massper)
Interventional
N/A
University Hospital, Caen (Voir sur ClinicalTrials)
octobre 2013
29 juin 2024
Parabolic flight is the only ground-based condition in which free-fall (0G) can be
created long enough for safely testing changes in human perception and behavior. In
addition to the 0G period, parabolic flight generates equal duration periods of 1.8G,
which present another unique opportunity to test the same responses to hypergravity and
back to 1G.
It is well known that performance decrements occur in astronauts during and after gravity
level transitions. Illusions are commonly felt in orbit as well disorientation and
perceptual limitations, mainly due to both psycho-physiological changes and adaptation
and lack of familiar points of reference in the space environment. Studies performed
during previous space missions showed several changes occurring in different gravity
conditions, pointing out, for example, that colors and shadows were misleading, the depth
and distance perception were weakened, and the linear perspective was lost. Visual
perception is of primary importance for spatial orientation and object recognition
because the static vestibular (otolithic) and proprioceptive signals are absent when
free-floating. Consequently, astronauts become increasingly dependent on vision to
perceive motion and orientation. All these factors play an important role in the
adaptation of humans to spaceflight that needs to be analyzed to understand the
underlying mechanisms that regulate human psycho-physiological adaptive process to
changing gravity. Human psycho-physiological health has to be safeguarded and possibly
improved when long-term human space missions are programmed in the near future.
The primary objective of this experiment is to investigate if the SWI illusion is present
in altered gravity environments. Since weight cannot be estimated in 0G, investigators
have developed a procedure during which the subject is asked to estimate the objects'
mass by shaking them rather than lifting them. Our results in 1G indicate that a
size-mass illusion (SMI) is also present in 1G. Our hypothesis is that the previously
observed alteration in 3D visual perception in 0G, particularly in the height of 3D
objects, as well as the change in proprioceptive inputs, will be responsible for changes
in the SMI in 0G and 1.8G compared to 1G. In a separate proposal, investigators will also
propose to perform this experiment using the ESA short-arm human centrifuge (SAHC), with
subjects exposed to various centrifugal force levels, to further investigate the role of
proprioceptive cues in the size-mass illusion.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| Umr Ucbn/Inserm U1075 Comete - 14032 - Caen CEDEX - Basse-Normandie - France | Pierre Denise, MD PhD | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Healthy volunteers (men or women)
- Aged from 21 to 65
- Right handed
- Affiliated to a Social Security system and, for non-French resident, holding a
European Health Insurance Card (EHIC)
- Who accepted to take part in the study
- Who have given their written stated consent
- Who has passed a medical examination similar to a standard aviation medical
examination for private pilot aptitude (JAR FCL3 Class 2 medical examination). There
will be no additional test performed for subject selection.
- Healthy volunteers (men or women)
- Aged from 21 to 65
- Right handed
- Affiliated to a Social Security system and, for non-French resident, holding a
European Health Insurance Card (EHIC)
- Who accepted to take part in the study
- Who have given their written stated consent
- Who has passed a medical examination similar to a standard aviation medical
examination for private pilot aptitude (JAR FCL3 Class 2 medical examination). There
will be no additional test performed for subject selection.
- Person who took part in a previous biomedical research protocol, of which exclusion
period is not terminated
- Pregnant women