Informations générales (source: ClinicalTrials.gov)

NCT02565095 Statut inconnu
Interaction of Otolith Stimulation and Carotid Baroreflex in Humans (OTOBAR)
Interventional
N/A
University Hospital, Caen (Voir sur ClinicalTrials)
mars 2009
29 juin 2024
It is well documented that a few days stay in space induces a change in the vestibular-ocular reflex reflecting a reinterpretation of sensory inputs following the disappearance of gravity. If the change of eye reflexes actually the result of a reinterpretation of sensory input, the investigators should also expect to see an alteration of the vestibular-cardiovascular reflexes. The modification of these reflexes may modulate the carotid baroreflex and thus participate in the post-flight cardiovascular deconditioning. The first objective of this project is to study the carotid baroreflex under different supine (dorsal, ventral and lateral) inducing different otolith stimulation in normal-gravity.
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Etablissements

Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données
Laboratoire de Physiologie, CHU de Caen - 14000 - Caen - France Hervé Normand En recrutement Contact (sur clinicalTrials)

Critères

Tous
Inclusion Criteria:

- Healthy volunteers, male and / or female aged 18-30 years

- subject affiliated to a social security scheme, agreeing to participate in the study
and who provided informed consent.


- who participated in a clinical trial within less than the period of exclusion from
this project

- with a past or present history of heart disease, vascular, neurological,
respiratory, rheumatological, metabolic or otologic.

- pregnant women (dosage beta HCG)

- having taken any medication heart, vascular, neurological, respiratory,
rheumatological, metabolic or might interfere on vestibular test results during the
two years preceding the experiment.

- smoking or smoking more than 5 cigarettes / day, 1 cigarette / day or 1 pipe / day