Informations générales (source: ClinicalTrials.gov)
Adapted Physical Activity Effect on Aerobic Function and in Patients in Pre Liver Transplantation (FAPA)
Interventional
N/A
University Hospital, Limoges (Voir sur ClinicalTrials)
juillet 2016
mars 2021
29 juin 2024
Physical exercise has been identified as a major beneficial factor in the management of
patients suffering from many chronic diseases especially cancer and in the context of
cardiac or pulmonary transplantation. It contributes to an improvement of the quality of
life and decreases treatment side effects and mortality. Aerobic fitness is constantly
altered in cirrhotic patients and correlated to the severity of the hepatic disease.
Moreover, in this setting, other etiological factors may be added like chronic
obstructive bronchitis and alcoholic cardiomyopathy. In this population, muscle
abnormalities with fatigue and cramps have been described. Muscle weakness in this
condition may be comparable to that described in patients with chronic obstructive
bronchitis and contributes to the decrease of aerobic fitness. Different causes such as
muscle deconditioning, hypoxemia, denutrition, anti-rejection drugs increase this
phenomenon after liver transplantation. Finally, the aerobic capacity or VO2max is a
prognostic factor for survival and is linked to the number and the length of
hospitalizations after liver transplantation (LT).
Therefore, physical activity is a valid and relevant way to improve quality of life,
increase survival, and limit costs of hospitalizations. The aim of this study is to
assess the effects of a personalized physical activity retraining program on aerobic
capacity, strength and fatigue, in a population awaiting liver transplantation.
Purpose: The hypothesis is that an at home adapted retraining program conducted before
LT, and including physical activity (aerobic and strength training), will improve aerobic
fitness, peripheral strength, quality of life and decrease the hospitalization length in
intensive care unit after LT.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| Limoges Hospital - 87 042 - Limoges - France | maryline DEBETTE GRATIEN, MD | Contact (sur clinicalTrials) | |||
| Tours hospital - Tours - France | Ephrem SALAME, MD | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Males and females between 18 and 70 years of age,
- Signed informed consent,
- Medical indication to LT whatever the cause of the liver disease
- Males and females between 18 and 70 years of age,
- Signed informed consent,
- Medical indication to LT whatever the cause of the liver disease
- Inability to understand the instructions of the trial,
- Patients who are subject to a court protection, wardship or guardianship order,
- Uncontrolled cardiac disease and ventricular ejection fraction (vef) < 50 %,
- Any other serious conditions which are not stabilized and in which physical exercise
is contra-indicated,
- Pregnancy or suckling,
- Patients transplanted in extreme emergency.