Informations générales (source: ClinicalTrials.gov)
Association Between Cerebral Arterial Vascular Flow and Sleep Apnea in Neurodegenerative Alterations
Interventional
N/A
Central Hospital Saint Quentin (Voir sur ClinicalTrials)
mai 2015
janvier 2022
13 septembre 2025
Obstructive sleep apnea syndrome (OSAS) is a sleep-disordered breathing characterized by
the occurrence of repeated upper airway obstructions leading to airflow reduction
(hypopnea) or cessation (apnea). The apnea-hypopnea index (AHI) is the number of apneas
and hypopneas per hour of sleep. OSA patients often report cognitive complaints.
About 25% of the elderly population is affected by this syndrome with a drastic increase
of this rate among dementia patients. OSAS is considered to be an important risk factor
for the development of hypertension, heart disease and stroke.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CH Saint-Quentin - 02100 - Saint-Quentin - France | ATTIER-ZMUDKA Jadwiga, PH | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
1. Elderly patients about or over 75 years
2. Any gender
3. Dementia Group:
3.1. MMSE (Mini Mental State Examination)> 15
3.2. Diagnosis of dementia established according to DSM-IV
3.3. Dementia of the Alzheimer type from NINCDS-ADRDA (National Institute of
Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and
Related Disorders Association)
4. Control Group:
Preserved cognitive function corresponding to a normal MMSE score by the standards
of Poitrenaud
5. Ability to understand and give consent freely (for demented subjects, a legal
representative will be delegate)
1. Elderly patients about or over 75 years
2. Any gender
3. Dementia Group:
3.1. MMSE (Mini Mental State Examination)> 15
3.2. Diagnosis of dementia established according to DSM-IV
3.3. Dementia of the Alzheimer type from NINCDS-ADRDA (National Institute of
Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and
Related Disorders Association)
4. Control Group:
Preserved cognitive function corresponding to a normal MMSE score by the standards
of Poitrenaud
5. Ability to understand and give consent freely (for demented subjects, a legal
representative will be delegate)
1. Elderly patients under 75 years
2. Anyone with a classic contraindication to MRI
2.1 Major behavioral disorders that do not allow the realization of MRI in optimal
conditions
2.2 Claustrophobia
2.3 Presence of foreign non-compliant material
2.4 Presence of intraocular metal body
3. Having a history of chest surgery or neurosurgical
4. Chronic respiratory failure
5. Suffering from dementia other than that associated with Alzheimer's disease
6. Patients with a handicap
7. Patients under legal protection