Informations générales (source: ClinicalTrials.gov)
A Randomized Double-blind Phase II Trial Evaluating Maintenance Olaparib Versus Placebo in Patients With Platinum-sensitive Advanced Non-small Cell Lung Cancer (PIPSeN)
Interventional
Phase 2
Gustave Roussy, Cancer Campus, Grand Paris (Voir sur ClinicalTrials)
janvier 2016
janvier 2021
29 juin 2024
This is a multicentre randomised double-blind phase II trial, sponsored by Gustave Roussy
and involving one French center as well as the Spanish Lung Cancer Group (≈20 centers of
the SLCG).
Six hundred patients with diagnosis of stage IIIB/IV NSCLC will initially be registered
prior to receiving the first line platinum-based chemotherapy or during or at the end of
the first 6 cycles of inducation platinium based chemotherapy and provide consent for
retrieving archival tissue collection and providing translational blood samples and tumor
biopsies.
1.
- Induction chemotherapy phase All patients will initially be treated with 6
cycles of platinum-based induction chemotherapy. Cycle duration will be 21
days. Doublets should either consist of a pemetrexed-platinum (cisplatin or
carboplatin) doublet (preferentially for non-squamous NSCLC) or a gemcitabine -
or vinorelbine - platinum doublet for squamous NSCLC. Taxanes-platinum doublets
will not be accepted. Translational blood samples will be taken at the
beginning of induction chemotherapy for all patients.
Patients displaying progressive disease or stable disease after induction
chemotherapy will be withdrawn and further optimally managed according to local
practice. For them, an optional tumour biopsy will be performed at the end of the
induction treatment.
2.
- Randomisation and maintenance phase Only patients who respond to platinum-based
induction chemotherapy will be further randomised between olaparib and placebo.
These patients must have been treated with 6 cycles of chemotherapy. However,
patients who haven't received 6 cycles of the induction chemotherapy due to
severe toxicity (grade 3 or 4, NCI CTCAE v4.0) could be randomized only if they
had received 4 chemotherapy cycles at least and if all treatment related
toxicities are resolved to a grade ≤ 1 (NCI CTCAE v4.0).
Treatment will be administered at a dose of 600 mg daily (2 doses of 300 mg [2 tablets of
150 mg] taken approximately 12 hours apart) and cycle duration will be 28 days. Disease
will be assessed every 2 cycles by CTscan (MRI or PET-scan if the scan is not
contributive) and treatment will be administered until disease progression or
unacceptable toxicity. Patients will then be optimally managed according to local
practice. Follow-up will be for a minimum of 15 months from the time of randomization,
and until last venue. All randomised patients will be asked to provide translational
blood samples at randomization, on treatment and at the end of the treatment. Optional
tumour biopsies will be performed at randomization, at the end of the treatment (or at
disease progression if available).
Etablissements
| Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CLCC INSTITUT GUSTAVE ROUSSY | Valérie Mairot | Contact (sur clinicalTrials) | |||
Critères
Tous
For inclusion in the study subjects should fulfill the following criteria:
1. Provision of written informed consent to treatment and companion translational
studies prior to any study specific procedures
2. Patients must be > 18 years of age.
3. Affiliation to an health insurance
4. Histological diagnosis of NSCLC
5. Advanced or metastatic disease (stage IIIB/IV)
6. Access to the original tumor biopsy or planning of a fresh tumor biopsy before start
the platinium based chemotherapy
7. Chemonaive for NSCLC or patient having received adjuvant chemotherapy at least 2
years before trial enrolment or patient currently receiving his/her first
platinum-based chemotherapy for advanced NSCLC (first line or second line only if
the first line was an anti-PD-1 or anti-PD-L1 agent monotherapy)
8. No other cancer in the previous 3 years, except cervical cancer or cutaneous cancer
9. Absence of EGFR-sensitising mutation or ALK translocation
10. ECOG Performance Status of 0-1
11. Fit to receive 6 cycles or currently receiving of platinum-based induction
chemotherapy
12. At the start of the platinium based induction chemotherapy measurable lesions by
RECIST v1.1 criteria, i.e. at least one lesion, not previously irradiated, that can
be accurately measured at baseline as ≥ 10mm in the longest diameter (except lymph
nodes that must have short axis ≥ 15mm) with computed tomography (CT), magnetic
resonance imaging (MRI) or clinical examination and which is suitable for accurate
repeated measurements.
Inclusion criteria 13 is only for patients registered before starting the
platinum-based induction chemotherapy:
13. Patients must have normal organ and bone marrow function measured within 14 days
prior to administration of the platinum based treatment
- Haemoglobin ≥ 10.0 g/dL
- Absolute neutrophil count (ANC) ≥ 1.5 x 109/L
- Platelet count ≥ 100 x 109/L
- Total bilirubin ≤ 1.5 x institutional upper limit of normal (ULN)
- AST (SGOT)/ALT (SGPT) ≤ 2.5 x institutional upper limit of normal unless liver
metastases are present in which case it must be ≤ 5x ULN
- Creatinine clearance > 60mL/min as calculated by Cockroft-Gault formula for
cisplatin administration; creatinine clearance >/= 51mL/min by Cockroft-Gault
formula for carboplatin administration
14. Evidence of non-childbearing status for women of childbearing potential: negative
serum pregnancy test within 14 days of study treatment.
Postmenopausal is defined as:
- Amenorrheic for 1 year or more following cessation of exogenous hormonal
treatments,
- LH and FSH levels in the post-menopausal range for women under 50,
- Radiation-induced oophorectomy with last menses >1 year ago,
- Chemotherapy-induced menopause with >1 year interval since last menses,
- Or surgical sterilisation (bilateral oophorectomy or hysterectomy).
15. Both men and women (of childbearing potential) who are sexually active should accept
to use adequate contraception, during and for at least 6 months post-treatment
16. Patient is willing and able to comply with the protocol for the duration of the
study including undergoing treatment and scheduled visits and examinations including
follow up.
17. Previous surgery (in the adjuvant setting) for NSCLC, radiotherapy (with a curative
intent for local or locally-advanced disease) or immunotherapy by anti- PD-1 or
anti-PD-L1 agent in the metastatic setting are allowed
Non-inclusion criteria:
1. Uncontrolled or symptomatic brain metastases. Controlled brain metastases are
defined as stable for 1 month. A scan to confirm the absence of brain metastases is
not required. Corticosteroids therapy will be allowed if administered at a stable
dose for at least one month before entering the trial.
2. Previous enrolment (or randomisation) in the present study Any previous systemic
treatment for cancer in the previous 3 years.
3. Any previous systemic treatment for cancer in the previous 3 years except for NSCLC.
4. Patients receiving any radiotherapy or considering to require radiotherapy to the
lung at the time of study entry or in the near future, except for palliative
reasons. The patient can receive a stable dose of bisphosphonates for bone
metastases, before and during the study as long as these were started at least 4
weeks prior to inclusion.
5. Patients receiving the following classes of inhibitors of CYP3A4 (see Section 6.5
for guidelines and wash out periods).
- Azole antifungals
- Macrolide antibiotics
- Protease inhibitors
6. Major surgery within 14 days before to start the induction chemotherapy and patients
who have not recovered from any effects of any major surgery.
7. Patients considered a poor medical risk due to a serious, uncontrolled medical
disorder, non-malignant systemic disease or active, uncontrolled infection. Examples
include, but are not limited to, uncontrolled ventricular arrhythmia, coronary
artery disease, cardiomyopathy, uncontrolled hypertension, myocardial infarction in
the last 3 months, unstable spinal cord compression (untreated and unstable for at
least 28 days prior to start the induction chemotherapy), superior vena cava
syndrome, extensive bilateral lung disease on HRCT scan or any psychiatric disorder
that prohibits obtaining informed consent.
8. Pregnant and/or breast-feeding women.
9. Patients who are known to be serologically positive for human immunodeficiency virus
(HIV) and/or are receiving antiviral therapy. Systematic serologies to confirm the
absence of this disease are not required.
10. Patients with known active hepatic disease (i.e., Hepatitis B or C) Systematic
serologies to confirm the absence of these diseases are not required.
11. Patients with a known hypersensitivity to olaparib/placebo, cisplatin, carboplatin,
or other platinum containing compounds, or any of the excipients of the product.
12. Concomitant yellow fever vaccine
13. Patients unable to swallow orally administered medication and patients with
gastrointestinal disorders likely to interfere with absorption of olaparib/placebo.
14. Symptomatic peripheral neuropathy ≥ grade 2
15. Patients with uncontrolled seizures
16. Patients with myelodysplastic syndrome/acute myeloid leukaemia.
17. Enrolment in another clinical trial (except observational study).
1. Provision of written informed consent to treatment and companion translational
studies prior to any study specific procedures
2. Patients must be > 18 years of age.
3. Affiliation to an health insurance
4. Histological diagnosis of NSCLC
5. Advanced or metastatic disease (stage IIIB/IV)
6. Access to the original tumor biopsy or planning of a fresh tumor biopsy before start
the platinium based chemotherapy
7. Chemonaive for NSCLC or patient having received adjuvant chemotherapy at least 2
years before trial enrolment or patient currently receiving his/her first
platinum-based chemotherapy for advanced NSCLC (first line or second line only if
the first line was an anti-PD-1 or anti-PD-L1 agent monotherapy)
8. No other cancer in the previous 3 years, except cervical cancer or cutaneous cancer
9. Absence of EGFR-sensitising mutation or ALK translocation
10. ECOG Performance Status of 0-1
11. Fit to receive 6 cycles or currently receiving of platinum-based induction
chemotherapy
12. At the start of the platinium based induction chemotherapy measurable lesions by
RECIST v1.1 criteria, i.e. at least one lesion, not previously irradiated, that can
be accurately measured at baseline as ≥ 10mm in the longest diameter (except lymph
nodes that must have short axis ≥ 15mm) with computed tomography (CT), magnetic
resonance imaging (MRI) or clinical examination and which is suitable for accurate
repeated measurements.
Inclusion criteria 13 is only for patients registered before starting the
platinum-based induction chemotherapy:
13. Patients must have normal organ and bone marrow function measured within 14 days
prior to administration of the platinum based treatment
- Haemoglobin ≥ 10.0 g/dL
- Absolute neutrophil count (ANC) ≥ 1.5 x 109/L
- Platelet count ≥ 100 x 109/L
- Total bilirubin ≤ 1.5 x institutional upper limit of normal (ULN)
- AST (SGOT)/ALT (SGPT) ≤ 2.5 x institutional upper limit of normal unless liver
metastases are present in which case it must be ≤ 5x ULN
- Creatinine clearance > 60mL/min as calculated by Cockroft-Gault formula for
cisplatin administration; creatinine clearance >/= 51mL/min by Cockroft-Gault
formula for carboplatin administration
14. Evidence of non-childbearing status for women of childbearing potential: negative
serum pregnancy test within 14 days of study treatment.
Postmenopausal is defined as:
- Amenorrheic for 1 year or more following cessation of exogenous hormonal
treatments,
- LH and FSH levels in the post-menopausal range for women under 50,
- Radiation-induced oophorectomy with last menses >1 year ago,
- Chemotherapy-induced menopause with >1 year interval since last menses,
- Or surgical sterilisation (bilateral oophorectomy or hysterectomy).
15. Both men and women (of childbearing potential) who are sexually active should accept
to use adequate contraception, during and for at least 6 months post-treatment
16. Patient is willing and able to comply with the protocol for the duration of the
study including undergoing treatment and scheduled visits and examinations including
follow up.
17. Previous surgery (in the adjuvant setting) for NSCLC, radiotherapy (with a curative
intent for local or locally-advanced disease) or immunotherapy by anti- PD-1 or
anti-PD-L1 agent in the metastatic setting are allowed
Non-inclusion criteria:
1. Uncontrolled or symptomatic brain metastases. Controlled brain metastases are
defined as stable for 1 month. A scan to confirm the absence of brain metastases is
not required. Corticosteroids therapy will be allowed if administered at a stable
dose for at least one month before entering the trial.
2. Previous enrolment (or randomisation) in the present study Any previous systemic
treatment for cancer in the previous 3 years.
3. Any previous systemic treatment for cancer in the previous 3 years except for NSCLC.
4. Patients receiving any radiotherapy or considering to require radiotherapy to the
lung at the time of study entry or in the near future, except for palliative
reasons. The patient can receive a stable dose of bisphosphonates for bone
metastases, before and during the study as long as these were started at least 4
weeks prior to inclusion.
5. Patients receiving the following classes of inhibitors of CYP3A4 (see Section 6.5
for guidelines and wash out periods).
- Azole antifungals
- Macrolide antibiotics
- Protease inhibitors
6. Major surgery within 14 days before to start the induction chemotherapy and patients
who have not recovered from any effects of any major surgery.
7. Patients considered a poor medical risk due to a serious, uncontrolled medical
disorder, non-malignant systemic disease or active, uncontrolled infection. Examples
include, but are not limited to, uncontrolled ventricular arrhythmia, coronary
artery disease, cardiomyopathy, uncontrolled hypertension, myocardial infarction in
the last 3 months, unstable spinal cord compression (untreated and unstable for at
least 28 days prior to start the induction chemotherapy), superior vena cava
syndrome, extensive bilateral lung disease on HRCT scan or any psychiatric disorder
that prohibits obtaining informed consent.
8. Pregnant and/or breast-feeding women.
9. Patients who are known to be serologically positive for human immunodeficiency virus
(HIV) and/or are receiving antiviral therapy. Systematic serologies to confirm the
absence of this disease are not required.
10. Patients with known active hepatic disease (i.e., Hepatitis B or C) Systematic
serologies to confirm the absence of these diseases are not required.
11. Patients with a known hypersensitivity to olaparib/placebo, cisplatin, carboplatin,
or other platinum containing compounds, or any of the excipients of the product.
12. Concomitant yellow fever vaccine
13. Patients unable to swallow orally administered medication and patients with
gastrointestinal disorders likely to interfere with absorption of olaparib/placebo.
14. Symptomatic peripheral neuropathy ≥ grade 2
15. Patients with uncontrolled seizures
16. Patients with myelodysplastic syndrome/acute myeloid leukaemia.
17. Enrolment in another clinical trial (except observational study).