Informations générales (source: ClinicalTrials.gov)

NCT02789059 Statut inconnu
Muscle Oxygenation Modification During Effort in 4 Groups of Neuromuscular Diseases Compared to Healthy Controls, and Mitochondrial Function and Phenotype Assessment (OXYNEMU)
Interventional
  • Maladies neuromusculaires
N/A
University Hospital, Lille (Voir sur ClinicalTrials)
juillet 2015
juillet 2017
29 juin 2024
Previous studies showed modifications of muscle oxygenation parameters in muscular dystrophies du to an impairment or an absence of dystrophin. Our study aim at assessing muscle oxygenation during effort in different neuromuscular diseases (muscular dystrophies related and not related to dystrophin, non dystrophic myopathies and motor neuron diseases) compared to a group of healthy controls. Patients and controls are invited to perform an inframaximal , standardized effort of the knee extensors by the mean of an isokinetic dynamometer. Muscle oxygenation parameters are assessed through a Near Infrared Spectroscopy (NIRS) Device. In patients affected by dystrophin related myopathies, a muscle biopsy will be performed in order to analyse mitochondrial oxygenation parameters and mitochondrial phenotype. Our Hypothesis is that muscle oxygenation is impaired in dystrophin related muscular dystrophies compared to other neuromuscular diseases and healthy controls because of lack of muscle capillary vessels dilatation during effort and impairment of mitochondrial function.
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Etablissements

Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données
CHRU de Lille, Hôpital Swyngedhauw - Lille - France Vincent TIFFEREAU, MD En recrutement Contact (sur clinicalTrials)
Hôpital Amiens Nord, Service de Neurologie - Amiens - France Philippe MERLE, MD,PhD Recrutement non commencé Contact (sur clinicalTrials)
Hôpital Sébastopol, CHU de Reims - Reims - France François BOYER, MD,PhD Recrutement non commencé Contact (sur clinicalTrials)

Critères

Homme
Inclusion Criteria:

- healthy subjects and

- subjects affected by one of the fallowing neuromuscular diseases: Becker Muscular
dystrophy Facioscapulohumeral dystrophy, Limb Girdle Muscular Dystrophy , Congenital
Myopathy , Spinal Muscular Atrophy Charcot Marie Tooth Disease and Amyotrophic
Lateral Sclerosis ,

- able to walk

- presenting a manual muscle testing of at Least 4/5 on the quadriceps according to
the Medical research Council


- musculoskeletal pain of the quadriceps

- other neurological disorders

- Heart failure arrhythmia, uncontrolled hypertension, angina pectoris

- dyspnoea >2 according to the NYHA

- Peripheral artery disease

- BMI >30kg.m-2.