Informations générales (source: ClinicalTrials.gov)

NCT02796040 Statut inconnu
Exploration of Mesocorticolimbic Pathway in Impulse Control Disorders in Parkinson's Disease: Study Using Tensor Diffusion Imaging and Tractography. (TCI-IRMdiff)
Interventional
  • Maladie
  • Troubles du contrôle des impulsions
  • Maladie de Parkinson
N/A
University Hospital, Clermont-Ferrand (Voir sur ClinicalTrials)
février 2016
août 2017
29 juin 2024
Impulse control disorders (ICD) are frequent in Parkinson's Disease. Neurobiological substrates of these symptoms are largely unknown. The investigators aim to explore mesocorticolimbic pathway in Parkinson's disease patients with impulse control disorders (ICD) using an MRI technique called tensor diffusion imaging (DTI). More precisely, the main purpose is to demonstrate that fractional anisotropy (FA) (data obtained with DTI) in the ventral tegmental area (VTA) is different between patients with ICD and patients without ICD. Secondary objectives are to demonstrate a difference in volume of VTA, in FA in others structures included in reward system (prefrontal cortex, nucleus accumbens, amygdala), and in number of fibers between VTA and the other structures of reward system between this two groups. Other objective is to measure and compare these same variables between Parkinson's patients and healthy controls. We hypothesized that a denervation of mesocorticolimbic pathway predisposes Parkinson's patients to ICD.
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Etablissements

Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données
CHU Clermont-Ferrand - 63003 - Clermont-Ferrand - France Patrick LACARIN En recrutement Contact (sur clinicalTrials)

Critères

Tous
Inclusion Criteria:

- Parkinson's disease (UK Parkinson's Disease Society Brain Bank Criteria)

- from 18 to 85 years old

- Impulse control disorder (one item ICD ≥2 at the scale ECMP : Evaluation
Comportementale de la maladie de Parkinson)


- Dementia (Mini Mental State < 26 or MATTIS < 130)

- Apathy (LARS (Lille Apathy Rating Scale) > 7)

- Depression (MADRS (Montgomery and Alsberg Depression Scale) ≥16

- Contra indication to MRI (claustrophobia, deep brain stimulation, pace maker...)