Informations générales (source: ClinicalTrials.gov)
Influence of Oxidative Stress and Nutrition Biomarkers on the Cognitive Decline Evolution in Alzheimer Disease (GERIOX)
Interventional
N/A
Hospices Civils de Lyon (Voir sur ClinicalTrials)
décembre 2014
décembre 2026
29 juin 2024
According to several reports, the oxidative stress and the nutrition could have an impact
in the Alzheimer disease.
The association of these two parameters measurements and the cognitive impairment decline
could help in a predictive diagnosis of cognitive decline evolution in patients
presenting cognitive disorders.
This is a monocentric prospective "routine care" clinical trial on patients showing
cognitive troubles especially memory complaints.
The objective is to demonstrate a correlation between oxydative stress and nutrition
biomarkers and the clinical evolution of patients complaining of cognitive impairments.
The neuropsychologic data collection (the mini mental Status Examination (MMSE), the
clock test, the Grober-Buschke test (FCSR-IR), the executive function evaluated by the
Trail making test, and the medical imaging (by magnetic resonance imaging (MRI) or
tomography in case of MRI contraindication) will be realized during the study inclusion
phase in the usual intake of patients. Whole blood samples for the oxydative and
nutrition biomarkers measurements will be taken at the study inclusion day during the
stay at the Day hospital dedicated to the routine intake of patients issued from the
memory consultation.
In this study, the principal evaluation criteria will be the MMSE score evolution during
the 60 months of the patients follow-up, measured during the routine visits scheduled
approximately every 6 months, according to the french national authority for health
recommendations. It will allow evaluating the correlation between the cognitive decline
evolution measured by MMSE during the Alzheimer disease or related diseases method during
the 2 years follow-up, and the oxydative stress blood markers.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| Service de Médecine Gériatrique. Groupement Hospitalier Sud. Hospices Civils de Lyon. - 69495 - Pierre Benite - France | Marc BONNEFOY, Pr | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- >55 years old patient
- Patient seen during a memory consultation in geriatric Unit, Lyon Sud University
Hospital
- Patient or legal representative and/or person of confidence who didn't express his
opposition to the clinical assay participation.
- Patient registered to the general social insurance
- Complementary health check scheduled at day hospital, conventional hospitalization
or regular consultation.
- >55 years old patient
- Patient seen during a memory consultation in geriatric Unit, Lyon Sud University
Hospital
- Patient or legal representative and/or person of confidence who didn't express his
opposition to the clinical assay participation.
- Patient registered to the general social insurance
- Complementary health check scheduled at day hospital, conventional hospitalization
or regular consultation.
- Patient unable to express his participation refusal and under curatorship or
unforced by the court of justice