Informations générales (source: ClinicalTrials.gov)
Simultaneous Determination of Blood Pressure by Oscillometry and Photoplethysmography Compared to the Standard Inert Gas Rebreathing Technique (CeCi)
Interventional
N/A
University Hospital, Caen (Voir sur ClinicalTrials)
avril 2015
avril 2018
29 juin 2024
Main objective of the experiment is threefold: 1) to technically test a device for
central blood pressure estimation for its applicability in a spaceflight-related
environment and on the International Space Station. 2) Furthermore the objective is to
compare central blood pressure estimates based on arterial pressure readings of different
peripheral arteries. For central blood pressure estimation mathematical transfer
functions as described by Karamanoglu and colleagues (11) will be used. 3) Finally the
experiments' objective is to simultaneously apply phonocardiography together with ECG and
carotid plethysmography to determine cardiac systolic time intervals in parabolic flight
during gravity transitions.
Secondary objective of the experiment is to simultaneously measure key variables of the
central circulation during gravity transitions to expand the understanding of
cardiovascular regulation in weightlessness. Furthermore spirometric measurements shall
be performed during a parabolic flight day to observe changes in end-expiratory CO2.
Arterial CO2 content is central for cardiovascular regulation.
Our main hypothesis is that there is no difference between different methods of central
arteria pressure determination.
Concerning our secondary objective, this experiment is designed as an observational
study. Thus no clear hypothesis was generated but the measured cardiovascular and
respiratory variables will be analysed regarding differences correlated to gravity.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| Caen CHU - 14000 - Caen - France | Contact (sur clinicalTrials) | ||||
Critères
Tous
Inclusion Criteria:
- Healthy volunteers (men or women)
- Aged from 18 to 65
- Affiliated to a Social Security system and, for non-French resident, holding a
European Health Insurance Card (EHIC)
- Who accepted to take part in the study
- Who have given their written stated consent
- Who has passed a medical examination similar to a standard aviation medical
examination for private pilot aptitude (JAR FCL3 Class 2 medical examination). There
will be no additional test performed for subject selection.
Subjects will be staff member of the team or of other teams participating in the
parabolic flight campaign
- Healthy volunteers (men or women)
- Aged from 18 to 65
- Affiliated to a Social Security system and, for non-French resident, holding a
European Health Insurance Card (EHIC)
- Who accepted to take part in the study
- Who have given their written stated consent
- Who has passed a medical examination similar to a standard aviation medical
examination for private pilot aptitude (JAR FCL3 Class 2 medical examination). There
will be no additional test performed for subject selection.
Subjects will be staff member of the team or of other teams participating in the
parabolic flight campaign
- Person who took part in a previous biomedical research protocol, of which exclusion
period is not terminated
- Treated or non-treated arterial hypertension
- Pregnant women