Informations générales (source: ClinicalTrials.gov)

NCT02809885 Statut inconnu
Hepatitis E Virus Infection in Pediatric Transplantation, a Prevalence Study (HEV)
Interventional
  • Hépatite
  • Maladies virales
  • Hépatite E
N/A
Hospices Civils de Lyon (Voir sur ClinicalTrials)
décembre 2013
décembre 2017
29 juin 2024
Hepatitis E virus (HEV) is an emerging disease. The genotype 1 and 2 are predominant in Asia and Africa, and are responsible for recurrent epidemics. Genotype 3 is the main genotype found in Europe and North America and is responsible for sporadic infections except for travel associated diseases. HEV had a principally asymptomatic form. However, it was recently demonstrated that it could lead to a chronic form, especially in immunosuppressed patients. Moreover, in liver transplanted patients the infection could mimic a rejection and lead to the loss of the transplant. In other immunosuppressed patients, chronic hepatitis lead to cirrhosis and its well-known complications (ascitis, digestive hemorrhage, liver failure...). There is a lack of information about the prevalence of this disease. In Canada the incidence of HEV infection was high (15-86% for liver transplanted children with liver tests disturbed). In Germany the prevalence was lower: 3,2% in liver & kidney transplanted children whereas 7,4% in control. It was shown in a retrospective study that in liver (and liver+kidney) transplanted children the prevalence in Lyon was around 8,3%. This study will determined in a prospective approach the HEV prevalence in kidney, lung, heart and bone marrow transplanted children in Lyon.
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Etablissements

Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données
Hospices Civils de Lyon - 69500 - Bron - France Noémie Laverdure, MD En recrutement Contact (sur clinicalTrials)

Critères

Tous
Inclusion Criteria:

- <18 years old

- transplantation (heart, kidney, lung or bone marrow)

- protocol acceptance by family

- social security available


- protocol rejection by family