Informations générales (source: ClinicalTrials.gov)
Tonsillectomy and Primitive IgA Nephropathy in Children: Strasbourg Cohort and Assessment Practices in Inter North East Region
Observational
University Hospital, Strasbourg, France (Voir sur ClinicalTrials)
avril 2016
septembre 2017
29 juin 2024
Primitive kidney disease IgA, represented by Berger's disease and rheumatoid purpura
nephropathy, are the first cause of kidney failure from chronic glomerulonephritis:
changes in 20 years to end-stage renal failure is described in 10 to 30 % of cases in
Berger's disease and in 15 to 20% of cases in nephropathy HSP. These two pathological
entities share biological and histological characteristics, as well as common
pathophysiological mechanisms, particularly the production of abnormally glycosylated
IgA1 promoting their proliferation in the mesangium. Tonsils part of Iga abnormal
production sites that would be associated with an infectious stimulus, tonsillectomy has
been studied as a possible treatment in primitive IgA nephropathy. The benefit of
tonsillectomy is controversial: many Japanese studies demonstrate its effectiveness in
terms of reduction of proteinuria, improved renal function in the long term regression of
histological lesions and reduced risk of relapse following clinical remission whereas
European studies do not suggest its effectiveness in treating IgA nephropathy. In this
context, the aim of our study is to describe the scope of practice of tonsillectomy in
the treatment of primary renal disease in IgA child in the inter East region and describe
the short renal become Strasbourg end of the cohort that received this treatment.
Etablissements
| Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| HOPITAL PEDIATRIE REEDUCATION BULLION | Laetitia HIGEL, MD | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion criteria:
- Children with a clinical diagnosis and / or histological evidence of primary IgA
nephropathy
- Follow the University Hospital of Strasbourg since 2009
- Having received a tonsillectomy in their care
- Children whose holders of parental authority does not oppose the use of clinical
data from their child for research purposes
- Children with a clinical diagnosis and / or histological evidence of primary IgA
nephropathy
- Follow the University Hospital of Strasbourg since 2009
- Having received a tonsillectomy in their care
- Children whose holders of parental authority does not oppose the use of clinical
data from their child for research purposes
- Children whose holders of parental authority are opposed to the use of clinical data
from their child for research purposes