Informations générales (source: ClinicalTrials.gov)
Measurement of Kidney Function Indexed Extracellular Volume Before and After Obesity Surgery in Kidney Patients With Severe Obesity or Massive
Interventional
N/A
Centre Hospitalier Universitaire de Nice (Voir sur ClinicalTrials)
mai 2015
décembre 2016
29 juin 2024
Obesity promotes chronic kidney disease and is accelerating its shift to the stage of
renal replacement. Bariatric surgery is a treatment for severe or morbid obesity whose
renal benefit is currently unknown. The glomerular filtration rate (GFR) is the best
parameter to define the kidney function. It can be estimated using formulas by assaying
endogenous markers (creatinine, cystatin C) or measured with an exogenous tracer
glomerular filtration (51 Cr-EDTA).
Bariatric surgery alters the production of endogenous markers and the extracellular
volume (VEC) with 2 important consequences on the assessment of GFR: the formula to
estimate GFR is not possible to compare renal function before and after surgery because
of the variation in production of endogenous glomerular filtration markers in the same
subject; decreasing VEC predicted decreased GFR after surgery, since these parameters are
in part proportional to each other.
Our working hypothesis is that bariatric surgery protects the kidneys of patients with
chronic kidney disease. To demonstrate this, investigators propose to compare the ratio
DFG / VEC before and after gastric bypass.
Goals The main objective is to measure the effect of gastric bypass on the report DFG /
VEC. Secondary objectives are to assess the effect of gastric bypass on the albumin /
urine creatinine and evaluate the performance of the main GFR estimating formulas in
people with severe or morbid obesity.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CHU de Nice - Nice - France | Guillaume FAVRE | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Topic GFR estimated by having the simplified formula of MDRD <60 ml / min / 1.73 m²
- Topic with BMI ≥ 40 kg / m², or ≥ 35 kg / m²
- Subject having at least one comorbidity could be improved after surgery after
failure of medical treatment: hypertension , OSAHS and other severe respiratory
disorders, severe metabolic disorders, particularly type 2 diabetes , debilitating
musculoskeletal diseases, steatohepatitis nonalcoholic .
- Topic who signed the informed consent
- Topic affiliated to the social security
- Male or female Topics
- Elderly 18 to 70 inclusive
- Topic GFR estimated by having the simplified formula of MDRD <60 ml / min / 1.73 m²
- Topic with BMI ≥ 40 kg / m², or ≥ 35 kg / m²
- Subject having at least one comorbidity could be improved after surgery after
failure of medical treatment: hypertension , OSAHS and other severe respiratory
disorders, severe metabolic disorders, particularly type 2 diabetes , debilitating
musculoskeletal diseases, steatohepatitis nonalcoholic .
- Topic who signed the informed consent
- Topic affiliated to the social security
- Male or female Topics
- Elderly 18 to 70 inclusive
- Non- Caucasian person because the necessary correction factors and not always
available for the formula to estimate GFR ( Cockcroft , Salazar and Corcoran ) .
- No major under guardianship
- Nobody hospitalized without his consent and not protected by law
- Private person of liberty
- Pregnant Woman, knowing that a pregnancy test will be performed for women of
childbearing age . Results will be communicated to the patient by a doctor of his
choice.
- Rapidly progressive glomerulonephritis
- Nephrotic proteinuria ranking