Informations générales (source: ClinicalTrials.gov)
Immuno-Génétique, Inflammation, Retro-Virus, Environnement (I-Give)
Interventional
N/A
Pr. Marion Leboyer (Voir sur ClinicalTrials)
novembre 2014
novembre 2025
29 juin 2024
Immunology combined to neurobiology now offer prominent tools to yield biomarkers, so far
missing in psychiatry, and to design innovative treatment approaches based on the
discovery of new molecular and cellular targets. As Bipolar Disorder and Schizophrenia
are now known to be significantly associated with neuro-inflammation, the project I-GIVE
will combine multidisciplinary approaches (clinical, viral, immunological, genetic) to
explore a global hypothesis placing the Human Endogenous Retro-Virus, HERV-W, at the
crossroads between susceptibility to environmental factors (such as winter-spring births,
infections, urbanicity...) and genetic factors controlling immune responses.
Thus I-GIVE will allow identification of new biomarkers and their correlation with
clinical profiles and immuno-inflammatory/immuno-genetic markers, and description of
patho-physiological mechanisms of a psychiatric disorder. In addition, I-GIVE should help
to design innovative treatments and foster personalized psychiatry tailored to the needs
of each patient. Notably, monoclonal antibodies anti-HERV-W Env will be assessed in a
preclinical model for their ability to slow, stop, or even reverse the progression of the
psychosis in patients. I-GIVE project should thus lead to major results that will have
strong impacts on the scientific community, pharmaceutical industries and, in a longer
term, on improvement of patients suffering Bipolar Disorder or Schizophrenia and their
family.
Etablissements
Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
---|---|---|---|---|---|
HOPITAL NOVO | Contact (sur clinicalTrials) | ||||
Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
EPS Maison Blanche - 75020 - Paris - France | Contact (sur clinicalTrials) | ||||
Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
Clinical Investigations Center of Mondor Hospital - 94000 - Créteil - France | Contact (sur clinicalTrials) | ||||
Psychiatry Department of Mondor Hospital - 94000 - Créteil - France | Contact (sur clinicalTrials) | ||||
Psychiatry Department of Perrens Hospital - Bordeaux - France | Contact (sur clinicalTrials) | ||||
Psychiatry Department of Widal Hospital - 75010 - Paris - France | Contact (sur clinicalTrials) |
Critères
Tous
Inclusion Criteria:
- Bipolar disorder or Schizophrenia (according to Diagnostic and Statistical Manual of
Mental Disorders IV)
- Bipolar disorder or Schizophrenia (according to Diagnostic and Statistical Manual of
Mental Disorders IV)
- pregnant women
- Vaccination within 4 precedent weeks
- Severe neurologic illness
- Immunosuppressing or immuno-modulating treatment.
- Infectious disease within 4 precedent weeks (including HIV 1 et 2, Hepatite B, C)
- Refuse to have HIV and hepatite B et C tests or to be informed of their results