Informations générales (source: ClinicalTrials.gov)
Study of Factors Associated With the Volumetric and Areal Bone Mineral Density and Bone Strength in Parkinson's Disease (PAFOS)
Observational
University Hospital, Clermont-Ferrand (Voir sur ClinicalTrials)
juin 2016
juillet 2022
29 juin 2024
Studies show that patients with idiopathic Parkinson's disease (IPD) have an increased
risk of fracture, particularly hip fracture whose complications and postoperative
mortality appear to be higher than in the general population.
This increased risk of fracture is due partly to an increased risk of falling, and
secondly to an impairment of bone tissue with lower bone mineral density (BMD). A
meta-analysis concluded that patients with IPD have lower BMD than healthy controls.
Prospective studies also showed rapid bone loss in these patients compared with controls.
The association between low BMD and IPD seems dependent on the severity and duration of
the disease even if some data are contradictory. Various mechanisms may explain this bone
loss including weight loss, malnutrition and a low level of physical activity. However,
enrollments in these studies are often weak and it is difficult to conclude on the real
impact of these factors on bone loss in the IPD. The main objective of our study is to
assess and prioritize from these various bone loss mechanisms. Bone assessment by
"peripheral quantitative computed tomography" (pQCT) will also assess the impact of
various risk factors on bone strength parameters. The prevalence of vertebral compression
fractures in the IPD, at this day unknown can be evaluated. This study will also estimate
the prevalence of vertebral compression fractures in the IPD.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CHU Clermont-Ferrand - 63003 - Clermont-Ferrand - France | Patrick LACARIN | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Idiopathic parkinson's disease (UKPDSBB criteria)
- Hoen and Yahr score < 4 (ON periods)
- Age between 35 and 70 years old
- Independent person at home
- Idiopathic parkinson's disease (UKPDSBB criteria)
- Hoen and Yahr score < 4 (ON periods)
- Age between 35 and 70 years old
- Independent person at home
- Dementia patient and progressive mental illness
- Patient with severe tremor
- Incapacity to walk over ten minutes
- Treatment influencing bone metabolism
- Disease influencing phosphocalcic metabolism
- Severe comorbidities
- Pregnant woman