Informations générales (source: ClinicalTrials.gov)
Oxidation Rates of the Different Substrates During Exercise in Children and Adolescents With Juvenile Idiopathic Arthritis. Case-control Study and Cases Treated / Cases Not Treated With Anti-TNFα (OSE-JIA)
Interventional
N/A
University Hospital, Clermont-Ferrand (Voir sur ClinicalTrials)
novembre 2016
septembre 2020
29 juin 2024
During exercise, energy comes mainly from carbohydrates and lipids. The relative
contribution of lipids and glucose as energy substrates to exercise depends on the
parameters of the exercise (duration, intensity and level of training) and the
physiological conditions of the subject.
Inflammatory diseases such as juvenile idiopathic arthritis (JIA) are treated, for the
most severe forms, by biotherapies. These treatments target certain pro-inflammatory
cytokines including TNFα. In adults with rheumatoid arthritis several studies have shown
that treatment with anti-TNFα increases insulin sensitivity. There is no data on the
oxidation of energy substrates during exercise in children and adolescents with AJI, nor
on the impact of anti-TNFα treatments on the oxidation of energetic substrates in
children.
Investigators hypothesize that, compared to healthy children, children with JIA should
exhibit altered oxidation of energy substrates at rest and submaximal physical exercise
due to physical deconditioning and inflammation. In addition, those treated with
anti-TNFα should have an oxidation profile of energy substrates at exercise different
from that of patients not treated with anti-TNFα. Investigators also hypothesize that
anti-TNFα treatments modify the contribution of energy chains (aerobic, anaerobic and
anaerobic alactic) during the exercise.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CHU Clermon-Ferrand - 63003 - Clermont-Ferrand - France | Patrick LACARIN | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Children with juvenile idiopathic arthritis
- Children with juvenile idiopathic arthritis
- active infection
- BMI > 25
- Systemic corticosteroid within last 3 months