Informations générales (source: ClinicalTrials.gov)
Diffusion Tensor Imaging of the Thalamo-cortical Network in Epilepsy With Continuous Spikes and Waves During Sleep (POCS-DTI)
Observational
University Hospital, Clermont-Ferrand (Voir sur ClinicalTrials)
janvier 2017
février 2020
29 juin 2024
Continuous Spikes and Waves during Sleep (CSWS) is a rare paediatric epileptic
encephalopathy. Even if the correlation between the severity of the epilepsy and the
cognitive consequences is well established, the mechanisms involved in epileptic
cognitive degradation are complex and poorly understood. In CSWS, there are many
arguments for the implication of cortical and subcortical cerebral structures. Among them
the thalamus seems to play a crucial role. In fact it is strongly implicated in the sleep
and this function is determining for learning. Moreover, it is part of the propagation
pathway of generalized forms of epilepsy like absences in animal studies. Unfortunately
there is no animal model for CSWS to confirm this theory. In human studies, few cases are
caused by thalamic injuries but most of the time conventional MRI is normal. Despite few
literature on CSWS, some studies reported abnormal functional connectivity especially in
the thalamus.
The investigators hypothesize that the first utilisation of diffusion tensor imaging
(DTI) and tractography will be useful in CSWS to confirm the implication of a
cortico-thalamo-cortical network showing an abnormal structural connectivity. The
investigators will try to determinate if a particular thalamic nucleus is concerned and
demonstrate a link between the disease severity (duration and cognitive consequences) and
the importance of structural abnormalities.
Using resting state functional MRI (fMRI), the investigators will also try to investigate
the default mode network. Its implication was also suggested in the literature.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CHU Clermont-Ferrand - 63003 - Clermont-ferrand - France | Patrick LACARIN | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
-
- for the patients, diagnosis of CSWS according to the current diagnostic
criteria (ILAE 2001)
- minimal age of 5 years old
- written consent to participate in the study from the subjects who could write and/or
from the parents or legal representative
-
- for the patients, diagnosis of CSWS according to the current diagnostic
criteria (ILAE 2001)
- minimal age of 5 years old
- written consent to participate in the study from the subjects who could write and/or
from the parents or legal representative
- rejection of the patient or its legal representative
- no respect of inclusion criteria