Informations générales (source: ClinicalTrials.gov)
Non Invasive Measurements of Intracranial Pressure After Aneurysmal Subarachnoid Hemorrhage (HEMAPIC)
Interventional
N/A
University Hospital, Clermont-Ferrand (Voir sur ClinicalTrials)
mars 2015
mars 2018
29 juin 2024
In patients at risk of increased intracranial pressure (ICP), ICP measurements require
invasive transducers, usually with insertion of a catheter into the cranium, or through a
spinal tap. These invasive modalities involve risks and pain and they can be done only in
specialized care units, with a high associated cost.
A novel method for detecting changes in ICP has developed recently. The auditory hair
cells emit sounds and electric signals in response to sound, which can be easily detected
and measured non-invasively with the help of a microphone probe placed in the external
ear canal or regular electrodes. Indeed, the cochlear aqueduct connects the cerebrospinal
fluid (CSF) spaces to the inner ear in such a way that ICP and inner-ear fluid pressure
equalize within seconds.
The evaluation of intracranial hypertension by increased ICP (invasive) is not
systematically used after aneurysmal subarachnoid hemorrhage. It is then detected by
using routine clinical signs of hydrocephalus or another disorder of cerebrospinal liquid
flow, in combination with a standard imaging method (TDM).
The measurement of noninvasive ICP could allow earlier detection of hydrocephalus or
another disorder of cerebrospinal liquid flow, and evaluate whether the increase in ICP
precedes patient clinical worsening and / or imaging.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| Chu Clermont-Ferrand - 63003 - Clermont-Ferrand - France | Patrick LACARIN | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Patients which had recently (few days) aneurysmal subarachnoid hemorrhage
- Valid tympanometry test at least for one ear
- Between 18 and 75 years of age
- Cochlear response useful at least for an ear which has validate the tympanometry
test
- Written informed consent reviewed and signed by patient
- Affiliation to a social security scheme
- Patients which had recently (few days) aneurysmal subarachnoid hemorrhage
- Valid tympanometry test at least for one ear
- Between 18 and 75 years of age
- Cochlear response useful at least for an ear which has validate the tympanometry
test
- Written informed consent reviewed and signed by patient
- Affiliation to a social security scheme
- Invalid tympanometry test for the both ears
- Collect of cochlear responses impossible for the ear or both ear which validate the
tympanometry test
- Patient refusal after enlightened information