Informations générales (source: ClinicalTrials.gov)

NCT03143413 Statut inconnu
Ultrasonography Features of the Salivary Glands in Patient With Systemic Sclerosis: Comparison With Gougerot-Sjogren Syndrome and Sicca Asthenia Polyalgia Syndrome
Observational
  • Asthénie
  • Sclérodermie systémique
  • Sclérose
  • Syndrome de Gougerot-Sjögren
  • Syndrome
  • Sclérodermie diffuse
University Hospital, Clermont-Ferrand (Voir sur ClinicalTrials)
mars 2017
mai 2019
29 juin 2024
Systemic sclerosis is an autoimmune connective tissue disease with undefined etiology and characterized by progressive fibrosis of the skin and major organs. Dry eyes and / or buccal syndrome is commonly reported in patients with systemic sclerosis. Goujerot-Sjogren syndrome is a chronic autoimmune disorder that is characterized by dryness of the eyes (xerophthalmia) and / or mouth (xerostomia). It may be primary or secondary to another connective tissue disease (such as lupus, rheumatoid arthritis or other). Several criteria have been validated to classify the SS but require a labial salivary gland biopsy, invasive act which complications can sometimes be reported (hematoma, lip sensory defect). Several scores based on the evaluation of the ultrasound homogeneity of the salivary glands were developed but no studies have evaluated ultrasound abnormalities of salivary glands in patients with systemic sclerosis.
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Etablissements

Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données
CHU Clermont-Ferrand - 63003 - Clermont-Ferrand - Auvergne - France Patrick LACARIN En recrutement Contact (sur clinicalTrials)

Critères

Tous
Inclusion Criteria:

- Systemic sclerosis diagnosis established by a rheumatologist and met ACR 2012
criteria

- Or primary Gougerot-Sjogren patient who met American-European Consensus Group (AECG)
classification criteria.

- Or patient presenting a sicca syndrome but not met Gougerot-Sjogren criteria


- History of radiotherapy on face and neck

- Infection such as VIH or Hepatitis C

- Sarcoidosis

- Amylosis

- Wearing contact lenses

- Hyper IgG4 syndrome