Informations générales (source: ClinicalTrials.gov)
Diagnosis Accuracy of Abdominal Compression and Hemoconcentration to Detect Diuretic Induced Fluid Removal Intolerance.
Observational
Hopital Louis Pradel (Voir sur ClinicalTrials)
mai 2017
décembre 2019
29 juin 2024
Fluid overload increases morbidity and mortality of pediatrics patients in intensive care
unit (ICU). It could be interesting to predict the decrease in stroke volume when
diuretics are prescribed. Nevertheless, no test predict a decrease of stroke volume in a
context of a diuretics induced depletion. Abdominal compression (AC) coupled with
echocardiographic measurement of the stroke volume can predict fluid responsiveness and
is a good tool to assess preload dependency. Another point is that during depletion
refilling can occur. We aim to assess the diagnostic accuracy of abdominal compression to
predict a decrease of the stroke volume of 15 % during diuretic-induced depletion of 10
ml/kg of diuresis. Secondary outcome will assess the hemoconcentration during depletion
to diagnose a decrease of stroke volume during diuretic induced depletion
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| Hopital Louis Pradel - 69100 - Bron - Rhone Alpes - France | Matthias Jacquet-Lagrèze, M.D., M.Sc. | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Height year old or less
- Patient hospitalized in the pediatric intensive care unit of the investigation
center.
presenting symptoms of fluid overload characterized with:
- Peripheral edema.
- An increase of 10% between the first day in ICU and inclusion date
- the attending physician should have decided to evaluate hemodynamic with
iterative echocardiography
- the attending physician, who is not the investigator has decided to administer
diuretics
- Height year old or less
- Patient hospitalized in the pediatric intensive care unit of the investigation
center.
presenting symptoms of fluid overload characterized with:
- Peripheral edema.
- An increase of 10% between the first day in ICU and inclusion date
- the attending physician should have decided to evaluate hemodynamic with
iterative echocardiography
- the attending physician, who is not the investigator has decided to administer
diuretics
- Patient or Holder of parental authority refusal to participate
- Dehydration with natremia over 150 mmol/L or clinical signs of dehydration
- Suspected abdominal hypertension
- recent abdominal surgery with abdominal pain induced by abdominal examination.