Informations générales (source: ClinicalTrials.gov)
Impact of Early Lactate Dosage Compared to CK for Diagnosis of a Suspected Seizure, on Patient Admitted to an Emergency Unit
Observational
University Hospital, Clermont-Ferrand (Voir sur ClinicalTrials)
novembre 2016
novembre 2018
29 juin 2024
Defining the origin of a seizure remains a difficult diagnosis. The presence of witness
is not systematic, the clinical examination can be little contributory, and the delay
recommended by the FSN is often surpassed for the realization of Creatine kinase (4h). In
the event of a suspected seizure, an initial blood test with Creatine kinase and Lactates
is often done on admission of the patient in other words before the 4hours delay.
It seems interesting to harmonize the practices, to limit the patient wait in the
emergencies for a deferred dosage of CK at 4 hours from the seizure and to identify an
early biological marker.
Objectives:
To evaluate the value of blood CK and Lactate dosage in emergency procedures in the
diagnosis of generalized seizures.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CHU de Clermont-Ferrand - 63003 - Clermont-Ferrand - Auvergne - France | Patrick LACARIN | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Any generalized convulsive seizure defined by a transient loss of consciousness with
the occurrence of tonic-clonic movements.
- Beginning less than 4 hours.
- In a highly evocative context of the crisis by the presence of: witnesses and/or
Urine loss, Tongue bite and/or personal medical history of epilepsy and/or Favorable
context: sleeping debt, drug withdrawal, lights stimulations, video games and/or
Impression of "already lived", already experienced before the discomfort and/or
Break contact, and/or Unusual posture with hypertonia and/or Amnesia of the episode
and/or Post-episode Confusion
- Inaugural or recurrent
- Any generalized convulsive seizure defined by a transient loss of consciousness with
the occurrence of tonic-clonic movements.
- Beginning less than 4 hours.
- In a highly evocative context of the crisis by the presence of: witnesses and/or
Urine loss, Tongue bite and/or personal medical history of epilepsy and/or Favorable
context: sleeping debt, drug withdrawal, lights stimulations, video games and/or
Impression of "already lived", already experienced before the discomfort and/or
Break contact, and/or Unusual posture with hypertonia and/or Amnesia of the episode
and/or Post-episode Confusion
- Inaugural or recurrent
- Patient Refusal
- <18 years
- Pregnancy
- Sepsis, fever> 38 °
- Shock State
- Myocardial infarction
- Unbalanced Diabetes
- Hepatocellular insufficiency
- Drug and Toxic Use
- Taking Metformin
- Significant muscle injuries
- Myopathy