Informations générales (source: ClinicalTrials.gov)
Multimodal Study of the Emotional Regulation and Impulsivity Among Adolescents with Borderline Personality Disorder : Stress Reactivity and Functional Imaging (ADOLIMIS)
Interventional
Phase 2
Institut National de la Santé Et de la Recherche Médicale, France (Voir sur ClinicalTrials)
octobre 2017
janvier 2026
05 avril 2025
This study aims to better understand the behavioral, neurobiological and hormonal
underpinnings of stress and reward reactivity of adolescents suffering from borderline
personality disorder compared to healthy adolescents by a multimodal approach based on
clinical assessments, structural and functional mri and experimental acute stress
exposure.
Etablissements
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| Pôle recherche clinique - 75013 - Paris - France | Contact (sur clinicalTrials) | ||||
Critères
Tous
Inclusion Criteria:
- Adolescent subject: 13 years ≤ age ≤ 18years
- Affiliation to social welfare
- Informed consent to participate in the protocol, consent signed by the major subject
or by one of the legal guardians if the subject is a minor
- Diagnosis of borderline personality disorder according to Diagnostic and Statistical
Manual of Mental Disorders 5 (DSM-5) and Abbreviated- Diagnostic Interview of
Borderline Personality Disorder (Ab-DIB)
- Somatic and intellectual state compatible with blood sampling and MRI examination
- Adolescent subject: 13 years ≤ age ≤ 18years
- Affiliation to social welfare
- Informed consent to participate in the protocol, consent signed by the major subject
or by one of the legal guardians if the subject is a minor
- Diagnosis of borderline personality disorder according to Diagnostic and Statistical
Manual of Mental Disorders 5 (DSM-5) and Abbreviated- Diagnostic Interview of
Borderline Personality Disorder (Ab-DIB)
- Somatic and intellectual state compatible with blood sampling and MRI examination
- Non-affiliation to social welfare
- Refusal to give consent and / or to sign informed consent by the subject or his or
her legal guardian if the subject is a minor
- Somatic pathology in progress, or pregnancy (urine test of pregnancy in case of
doubt)
- Contraindication to magnetic resonance imaging:
- Presence of a ferromagnetic foreign body
- Subject carrying a pacemaker
- Subject carrying ventricular bypass valves
- Claustrophobic topic
- Subject suffering from the following diseases:
- Intellectual impairment Intellectual Quotient (IQ) <70,
- Claustrophobia,
- Obsessive Compulsive Disorder,
- Tic Disorder,
- Autism Spectrum Disorder,
- Attention Deficit Disorder with or without Hyperactivity,
- Bipolar disorder,
- Schizophrenia