Informations générales (source: ClinicalTrials.gov)
Influence of Hyperoxia and Hypobaria on Atelectasis Occurrence and Mitigation of Atelectasis Formation
Interventional
N/A
Direction Centrale du Service de Santé des Armées (Voir sur ClinicalTrials)
septembre 2015
janvier 2020
29 juin 2024
The primary aim of this project is to get further knowledge of the physiology of flight
atelectasis and its prevention. We seek to: 1) assess whether low levels of positive
pressure breathing can prevent atelectasis formation in humans during exposure to
hyperoxia and +Gz-accelerations. 2) get further knowledge on the effects of hypobaria on
regional ventilation and perfusion.
A secondary aim is to evaluate the effect of anti G-trouser inflation on ventilation and
regional perfusion.
Etablissements
| Les établissements d'Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CTRE EXAMENS SANTE BRETIGNY SUR ORGE | Stephanie S Montmerle-Borgdorff, MD, PhD | Contact (sur clinicalTrials) | |||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Department of Radiology, Percy hospital - 92140 - Clamart - France | Contact (sur clinicalTrials) | ||||
Critères
Homme
Inclusion Criteria:
- normal lung function checked by pulmonary function tests.
- normal ECG
- normal clinical examination
Aim 1
- normal lung function checked by pulmonary function tests.
- normal ECG
- normal clinical examination
Aim 1
- smoking
- myopia
- past medical history of heart or lung disease
- current medical treatment for heart or lung disease
- past medical history of back pain or spine trauma or disease
- otitis
- bad tolerance to +Gz accelerations (G-induced loss of consciousness, motion
sickness)
- claustrophobia in the centrifuge gondola
Aim 2 exclusion criteria:
- smoking
- past medical history of heart or lung disease
- current medical treatment for heart or lung disease
- otitis
- bad tolerance to the altitude chamber (15,000 ft): ear pain, claustrophobia