Informations générales (source: ClinicalTrials.gov)
Acute Heart Failure - COngestion Repeated Evaluation (AHF-CORE). Evaluation répétée de la Congestion au Cours d'Une Hospitalisation Pour Insuffisance Cardiaque aigüe (AHF-CORE)
Interventional
N/A
Central Hospital, Nancy, France (Voir sur ClinicalTrials)
février 2018
février 2026
29 juin 2024
The AHF-CORE study is a prospective, non-randomized, multicenter regional study.
The main objective of the AHF-CORE study is to identify congestion markers (clinical,
biological and ultrasound) at the beginning and at the end of hospitalization for acute
heart failure that are more strongly associated with the risk of all cause death or
rehospitalization for acute heart failure within 3 months of hospital discharge.
Secondary objectives are:
- Quantify the variations in congestion markers between the beginning and end of
hospitalization for acute heart failure.
- Assess the correlation between changes in congestion markers between the beginning
and end of hospitalization.
- Identify the congestion markers at the beginning of hospitalization that are most
strongly associated with residual congestion at the end of hospitalization.
- Identify the added value of ultrasound and biological markers of congestion in
addition to clinical variables for the prediction of all-cause death or
hospitalization for acute heart failure at 3 months after hospital discharge.
- Identify the association of ultrasound and biologic congestion markers assessed at
admission and final discharge with NYHA class at 3 months after hospital discharge
Etablissements
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CHR Metz-Thionville - Hôpital de Mercy - 57000 - Metz - Lorraine - France | Contact (sur clinicalTrials) | ||||
| CHRU Nancy Hôpitaux de Brabois - 54500 - Vandœuvre-lès-Nancy - Lorraine - France | Contact (sur clinicalTrials) | ||||
Critères
Tous
Inclusion Criteria:
- Patients hospitalized for left-sided or global acute heart failure due to
exacerbation of chronic heart failure within 72 hours of admission to hospital
- Patients over 18 years old
- Person affiliated to or beneficiary of a social security plan
- Person informed about study organization and having signed the informed consent
- Patients hospitalized for left-sided or global acute heart failure due to
exacerbation of chronic heart failure within 72 hours of admission to hospital
- Patients over 18 years old
- Person affiliated to or beneficiary of a social security plan
- Person informed about study organization and having signed the informed consent
- Comorbidity for which life expectancy is ≤ 3 months
- Diagnosis of heart failure made less than 3 months prior to inclusion
- Exacerbation of heart failure attributed to acute ischemic stroke (acute coronary
syndrome with or without ST segment elevation)
- Dialyzed patient (peritoneal dialysis or hemodialysis) and patients with glomerular
filtration rate <15 ml / min / m2 at baseline
- History of pulmonary lobectomy or pneumonectomy
- Severe pulmonary or pleural disease preventing the reliable acquisition of pulmonary
ultrasound images: severe emphysema, chronic pleurisy, pulmonary fibrosis
- Suspected cardiac amylose or proven cardiac amylose
- Woman of childbearing age without effective contraception
- Persons referred in articles L.1121-5, L.1121-7, L.1121-8 and L.1122-2 of the French
Public Health Code: Pregnant, parturient or breastfeeding woman ; Minor person
(non-emancipated) ; Adult person under legal protection (any form of public
guardianship) ; Adult person incapable of giving consent and not under legal
protection.
- Persons deprived of liberty for judicial or administrative decision
- Persons subject to psychiatric care under articles L.3212-1 and L.3213-1 of the
French Public Health Code