Informations générales (source: ClinicalTrials.gov)
Comparison of Two Methods of Adjusting the Mechanical In-Exsuflation in Neuromuscular Adult Patients
Interventional
N/A
Assistance Publique - Hôpitaux de Paris (Voir sur ClinicalTrials)
mars 2019
décembre 2024
14 septembre 2025
In the context of neuromuscular diseases, the weakness of the respiratory muscles makes
difficult to manage periods of congestion due to a less effective cough. It exposes the
patient to bronchial superinfections that may require hospitalization. The use of cough
assistance is therefore essential in order to avoid acute situations such as bronchial
superinfections. Mechanical Insuflation-Exsufflation (MI / E) is an instrumental
technique commonly used by therapists in a hospital or at the patient's home in order to
facilitate the airway mucus clearance. The choice of the pressure settings of the IM / E
is a decisive point because it conditions the effectiveness of the generated cough. It'is
important to take into account the presence of any collapse in the use of IM / E in order
to ensure the most effective cough given by the patient. Actually, except the common
impression of the physiotherapist and the patient, there is no "simple" way for detecting
and objectifying the threshold of collapse in the upper airways.
The aim of this study is to compare two modalities for the regulation of the level of the
MI-E exsufflation, taking into account the presence of a collapse: a subjective "S"
adjustment based on the clinical judgment of the therapist and the patient and an
objective "O" adjustment based on the flow-volume curve generated during the cough.
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| GHI DU VEXIN SITE MAGNY | LOFASO Frederic | 25/10/2025 10:04:08 | Contacter | ||
| AP-HP Assistance publique - Hôpitaux de Paris | 25/10/2025 10:04:08 | Contacter | |||
| AP-HP - Hôpital Raymond Poincaré | |||||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Department of Physiology and Functional Explorations, Raymond Poincaré Hospital - 92380 - Garches - Hauts-de-Seine - France | Contact (sur clinicalTrials) | ||||
Critères
Tous
Inclusion Criteria:
- Aged ≥18 years
- Neuromuscular pathology
- Coughing aid information: DEPT <180 l / min
- In stable condition and without bulk
- Good understanding and cognition to follow the instructions and to inform the EVA
- Affiliated to a Sickness Insurance Plan or entitled
- Signed of informed consent
- Aged ≥18 years
- Neuromuscular pathology
- Coughing aid information: DEPT <180 l / min
- In stable condition and without bulk
- Good understanding and cognition to follow the instructions and to inform the EVA
- Affiliated to a Sickness Insurance Plan or entitled
- Signed of informed consent
- Pregnant woman
- Person under guardianship
- Inability to cooperate and / or communicate
- Acute decompensated organ
- Patient with following contraindications to mechanical in-exsufflation (MI-E)
devices:
1. pneumothorax
2. pneumomediastinum
3. pulmonary emphysema
4. hemoptysis
5. pleurisy
6. nausea
7. obstructive pulmonary disease or asthma
8. recent lobectomy of the lung
9. intracranial pressure