Informations générales (source: ClinicalTrials.gov)
Three-dimensional Analysis of EMMPRIN on Conjunctival Epithelial Cells Surface in Severe Dry Eye Syndrome (ALTESSE) (ALTESSE)
Observational
Fondation Ophtalmologique Adolphe de Rothschild (Voir sur ClinicalTrials)
décembre 2017
mars 2026
23 mai 2025
Modifications of cell surface markers (including EMMPRIN) were observed in conjunctival
epithelial cells during dry eye syndrome ; this study aims to describe the modifications
of the repartition of these cell surface markers before and after initiation of a
treatment.
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| HOPITAL FONDATION A. DE ROTHSCHILD | Daniel LEMAITRE | 19/12/2024 09:26:05 | Contacter | ||
Critères
Tous
Patients:
Inclusion criteria
- 18 years and over
- Severe eye dryness (grade 3 or 4) as defined by the International Dry Eye Work Shop
(2007): Frequent symptoms, Impregnation of fluorescein at the conjunctival level,
marked fluorescein staining at the corneal level, Tear Break Up Time ≤ 5 seconds
(fluorescein test) Schirmer's test score without anesthesia ≤ 5mm at 5 minutes
Exclusion criteria
- Treatment with topical ciclosporin
- Autologous serum treatment
- Wearer of scleral lenses
- Known pregnancy or breastfeeding
Control subjects:
Inclusion criteria
- 18 years and over
- Tear Break Up Time > 5 seconds (fluorescein test)
Exclusion criteria
- Wearer of contact lenses
- Functional ocular signs
- Anomalies of the ocular surface observed during examination with the slit lamp
- Fluorescein staining of the ocular surface (cornea, conjunctiva)
- Topical ocular treatment
- Known pregnancy or breastfeeding
Inclusion criteria
- 18 years and over
- Severe eye dryness (grade 3 or 4) as defined by the International Dry Eye Work Shop
(2007): Frequent symptoms, Impregnation of fluorescein at the conjunctival level,
marked fluorescein staining at the corneal level, Tear Break Up Time ≤ 5 seconds
(fluorescein test) Schirmer's test score without anesthesia ≤ 5mm at 5 minutes
Exclusion criteria
- Treatment with topical ciclosporin
- Autologous serum treatment
- Wearer of scleral lenses
- Known pregnancy or breastfeeding
Control subjects:
Inclusion criteria
- 18 years and over
- Tear Break Up Time > 5 seconds (fluorescein test)
Exclusion criteria
- Wearer of contact lenses
- Functional ocular signs
- Anomalies of the ocular surface observed during examination with the slit lamp
- Fluorescein staining of the ocular surface (cornea, conjunctiva)
- Topical ocular treatment
- Known pregnancy or breastfeeding