Informations générales (source: ClinicalTrials.gov)
Biological Dating of Cerebral Ischemia With Glutathion S-Transferase-π (GST-π) and Peroxyredoxin 1 (PRDX1) to Detect Patients With Stroke of Unknown Onset Within the Therapeutic Window of Thrombolysis (FLAG1)
Interventional
N/A
Central Hospital, Nancy, France (Voir sur ClinicalTrials)
octobre 2018
mars 2025
29 juin 2024
The FLAG1 study will assess the diagnostic performance of biomarkers Glutathion
S-Transferase-π (GST-π) and Peroxyredoxin 1 (PRDX1) to identify cerebral infarction of
less than 4,5 hours in a population of patients with neurological deficiency of less than
12 hours.
Etablissements
| Les établissements d'Île-de-France ayant mis à jour leurs données Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| HOPITAL FONDATION A. DE ROTHSCHILD | Candice SABBEN | 21/06/2024 13:32:51 | Contacter | ||
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Centre Hospitalier de Troyes - 10003 - Troyes - France | Anne AUBERTIN, MD | Contact (sur clinicalTrials) | |||
| Centre Hospitalier de Verdun - 55300 - Verdun - France | Sophie Marchal, MD | Contact (sur clinicalTrials) | |||
| Hôpital Central - 54000 - Nancy - France | Sébastien RICHARD, Professor | Contact (sur clinicalTrials) | |||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| Centre Hospitalier de Bar-Le-Duc - 55000 - Bar-le-Duc - France | Karine LAVANDIER, MD | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Patients over 18 years old
- Patients with symptoms consistent with stroke and a National Institute of Health
Stroke Score ≥3 at the inclusion time
- Time symptom onset ≤ 24 hours at inclusion:
- For patients with time of symptom onset is <4.5h at inclusion, the time of
symptom onset has to be precisely known, with a margin of error not exceeding
30 minutes (through patient or witness interview)
- For patients with time of symptom onset is >4.5h at inclusion, knowledge of
precise time of symptom onset is not required. For these patients, to ensure
onset-to-inclusion time is between 4.5 and 24 hours at inclusion:
- last time patient presented no deficit must be less than 24 hours,
- symptoms must have been first recognized more than 4.5 hours before blood draw.
- Possibility to perform MRI within the 30 minutes following blood collection
- Person affiliated to or beneficiary of a social security plan
- Patients over 18 years old
- Patients with symptoms consistent with stroke and a National Institute of Health
Stroke Score ≥3 at the inclusion time
- Time symptom onset ≤ 24 hours at inclusion:
- For patients with time of symptom onset is <4.5h at inclusion, the time of
symptom onset has to be precisely known, with a margin of error not exceeding
30 minutes (through patient or witness interview)
- For patients with time of symptom onset is >4.5h at inclusion, knowledge of
precise time of symptom onset is not required. For these patients, to ensure
onset-to-inclusion time is between 4.5 and 24 hours at inclusion:
- last time patient presented no deficit must be less than 24 hours,
- symptoms must have been first recognized more than 4.5 hours before blood draw.
- Possibility to perform MRI within the 30 minutes following blood collection
- Person affiliated to or beneficiary of a social security plan
- Persons referred in articles L.1121-5, L.1121-7, L.1121-8 and L.1122-2 of the French
Public Health Code: Pregnant, parturient or breastfeeding woman ; Minor person
(non-emancipated) ; Adult person under legal protection (any form of public
guardianship) ; Adult person incapable of giving consent and not under legal
protection.
- Persons deprived of liberty for judicial or administrative decision.
- Persons subject to psychiatric care under articles L.3212-1 and L.3213-1 of the
French Public Health Code.
- Known cancer in progression.
- Known cirrhosis.
- Myocardial Infarctions, stroke, Subarachnoid hemorrhage or intracranial injury
within 3 months prior to enrolment.