Informations générales (source: ClinicalTrials.gov)
Incidence of Neutropenic Enterocolitis Study in Acute Myeloid Leukemia Patients During Intensive Therapy (DECLAM).
Observational
Centre Hospitalier Universitaire, Amiens (Voir sur ClinicalTrials)
janvier 2019
novembre 2024
12 septembre 2025
Neutropenia after induction or consolidation therapy for acute myeloid leukemia (AML)
patients is associated with a high morbi-mortality rates, especially due to infectious
complications. These are managed according to international recommandations (ECIL and
IDSA) with antibiotherapy and antifungal strategy. Although the patients suffer of
digestive symptoms, intestinale complications are really less explored. Neutropenic
enterocolitis (NE), cytomegalovirus (CMV) colitis, Clostridium difficile colitis,
specific lesion, ischemic colitis are not well-known. No prospective study evaluate NE
and these digestive complications which have high morbi-mortality rates.
Etablissements
| Les établissements hors Île-de-France dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
|---|---|---|---|---|---|
| CHU de Caen - 14033 - Caen - France | Sylvain CHANTEPIE, PhD | Contact (sur clinicalTrials) | |||
| Henri Becquerel Center - 76038 - Rouen - France | Fabrince JARDIN, PhD | Contact (sur clinicalTrials) | |||
| Les établissements sans correspondance certaine dans le répertoire FINESS dont les données sont issues de ClinicalTrials.gov Origine et niveau de fiabilité des données | |||||
| CHU Amiens-Picardie - 80000 - Amiens - France | Delphine LEBON, Ph | Contact (sur clinicalTrials) | |||
Critères
Tous
Inclusion Criteria:
- Age > 18 years
- inclusion criteria:
Every patient of hematology:
- Able to receive an intensive treatment for AML (induction then intensive
consolidations) causing a neutropenia with high infectious risk
- In state to give its consent
- Affiliated to a social security system
- Age > 18 years
- inclusion criteria:
Every patient of hematology:
- Able to receive an intensive treatment for AML (induction then intensive
consolidations) causing a neutropenia with high infectious risk
- In state to give its consent
- Affiliated to a social security system
- The minor patients
- The patients affected by AML not being able to receive an intensive therapy
- The patients affected by acute promyelocytic leukaemia
- The pregnant women
- The patients with HIV, hepatitis B or C
- The patients under guardianship or guardianship or deprived of freedom by a court or
administrative order (according to articles L1121-6 and L1121-8 of the Public health
code)